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Proteomics profiling of inflammatory responses to elexacaftor/tezacaftor/ivacaftor in cystic fibrosis

Abstract: Background: CFTR modulator therapies have positive clinical outcomes, yet chronic inflammation and bacterial infections persist in people with CF (pwCF). How…

Date: 2025-01-28

Secondary neoplasms in survivors of pediatric acute lymphoblastic leukemia and lymphoblastic lymphoma: a single-center, retrospective study

Abstract: Background: Acute lymphoblastic leukemia (ALL)-based therapeutic regimens have markedly improved the survival of children with ALL and lymphoblastic lymphoma (LBL).…

Date: 2025-01-28

Analysis of risk factors for the development of obesity in preschool children: a logistic model analysis

Abstract: Introduction: Obesity, characterized by abnormal fat accumulation, has become a significant global health concern. The prevalence of obesity in preschool children is…

Date: 2025-01-28

Postnatal health of infants born to mothers with autoimmune diseases when treated with hydroxychloroquine

Abstract: Introduction: This retrospective cohort study aimed to observe the postnatal health of infants born to mothers with systemic autoimmune rheumatic diseases treated with…

Date: 2025-01-28

Identification of WDR74 and TNFRSF12A as biomarkers for early osteoarthritis using machine learning and immunohistochemistry

Abstract: Background: Osteoarthritis (OA) is a chronic joint condition that causes pain, limited mobility, and reduced quality of life, posing a threat to healthy aging. Early…

Date: 2025-01-28

Stigmatization of people with mental illness – a matter of milieu-specific worldviews? Results from a population-based survey in Germany

Abstract: Background: Despite numerous awareness campaigns and anti-stigma programs, people with mental illness, particularly schizophrenia, are still stigmatized. Although the…

Date: 2025-01-28

Co-design of the neurodevelopment assessment scale

Abstract: Introduction: Neurodevelopmental disorders (NDDs) have high comorbidity rates and shared etiology. Nevertheless, NDD assessment is diagnosis-driven and focuses on…

Date: 2025-01-28

Therapeutic drug monitoring and neutralizing anti-drug antibody detection to optimize TNF-alpha inhibitor treatment for uveitis

Abstract: Background: Adalimumab taken every other week is an effective treatment in patients with chronic refractory uveitis. Patients who have a suboptimal response to this…

Date: 2025-01-28

Single-cell RNA sequencing revealed PPARG promoted osteosarcoma progression: based on osteoclast proliferation

Abstract: Background: Osteosarcoma (OS) is one of the most common primary malignant bone tumors, primarily originating from mesenchymal tissue. It is notorious for its high…

Date: 2025-01-28

Do non-mammary conditions influence patients’ cosmetic perception after breast conserving surgery?

Abstract: Introduction: Compared to mastectomy, breast-conserving surgery (BCS) guarantees equivalent local control and survival, with lower morbidity and better quality of life…

Date: 2025-01-28