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Establishment of a prognostic signature and immune infiltration characteristics for uterine corpus endometrial carcinoma based on a disulfidptosis/ferroptosis-associated signature

Abstract: Background: Disulfidptosis and ferroptosis are two different programmed cell death pathways, and their potential therapeutic targets have important clinical prospects.…

Date: 2025-01-27

Study on influencing factors of age-adjusted Charlson comorbidity index in patients with Alzheimer's disease based on machine learning model

Abstract: Background: Alzheimer's disease (AD) is a widespread neurodegenerative disease, often accompanied by multiple comorbidities, significantly increasing the risk of death…

Date: 2025-01-27

Liposomal encapsulation of cholecalciferol mitigates in vivo toxicity and delays tumor growth

Abstract: Introduction: Vitamin D3 (cholecalciferol) has demonstrated potential anticancer properties, but its clinical application is limited by associated toxicity at effective…

Date: 2025-01-27

RET inhibition overcomes resistance to combined CDK4/6 inhibitor and endocrine therapy in ER+ breast cancer

Abstract: Background: Combined CDK4/6 inhibitor (CDK4/6i) and endocrine therapy significantly improve the outcome of patients with advanced estrogen receptor-positive (ER+) breast…

Date: 2025-01-27

Effect of drug interactions with apixaban on clinical outcomes in cancer patients with venous thromboembolism

Abstract: Introduction: It is unclear how drug-interaction with apixaban influences recurrent venous thromboembolism (VTE) and bleedings in cancer patients.

Date: 2025-01-27

Association of triglyceride-glucose-body mass index with all-cause mortality among individuals with cardiovascular disease: results from NHANES

Abstract: Background: The objective of this study was to explore the relationship between the triglyceride-glucose-body mass index (TyG-BMI) and all-cause mortality rate and to…

Date: 2025-01-27

Deciphering the role of metal ion transport-related genes in T2D pathogenesis and immune cell infiltration via scRNA-seq and machine learning

Abstract: Introduction: Type 2 diabetes (T2D) is a complex metabolic disorder with significant global health implications. Understanding the molecular mechanisms underlying T2D is…

Date: 2025-01-24

Association between balance ability and cardiovascular disease onsets among middle-aged and older adults: an observational cohort study from the China Health and Retirement Longitudinal Study

Abstract: Background: Previous studies showed the association between poor balance ability and a high risk of cardiovascular disease (CVD) mortality. However, there is little…

Date: 2025-01-24