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Association of ERAP1 and ERAP2 gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population

Abstract: Introduction: Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. Although RA is chiefly associated with HLA class II,…

Date: 2025-01-21

PCSK9-antibodies fail to block PCSK9-induced inflammation in macrophages and cannot recapitulate protective effects of PCSK9-deficiency in experimental myocardial infarction

Abstract: Background and aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a crucial role in cholesterol homeostasis by regulating low-density lipoprotein (LDL)…

Date: 2025-01-21

Deciphering the role of IL17RA in psoriasis and chronic mucocutaneous candidiasis: shared pathways and distinct manifestations

Abstract: Introduction: Psoriasis and chronic mucocutaneous candidiasis (CMC), although distinct in their clinical manifestations, often coexist within specific patient cohorts.…

Date: 2025-01-20

Prevalence and predictors of short stature in children aged 3–18 years in Hainan Province, China: a cross-sectional study

Abstract: Background: Short stature is a global health-related problem and remains to be evaluated in children in Hainan Province. The present study was conducted to investigate…

Date: 2025-01-20

Chinese medicine for headaches in emergency department: a retrospective analysis of real-world electronic medical records

Abstract: Background: Headaches are common complaints in the emergency department (ED) and have raised concern about acute medication overuse. Chinese medicine is a major…

Date: 2025-01-20

Infectious outcomes of a standardized subcutaneous immunoglobulin dose reduction strategy in primary immune deficiencies amid global shortage

Abstract: Introduction: Immunoglobulin replacement therapy (IgRT), either intravenous (IVIg) or subcutaneous (SCIg), is crucial for managing primary immune deficiencies (PIDs)…

Date: 2025-01-20

Identification of novel clinical subtypes in patients with microscopic polyangiitis using cluster analysis: multicenter REVEAL cohort study

Abstract: Introduction: This study aimed to identify new clinical phenotypes of microscopic polyangiitis (MPA) using a principal components analysis (PCA)-based cluster analysis.

Date: 2025-01-20

Prevalence and incidence of celiac disease in patients with rheumatoid arthritis: a case-control study based on the RECORD cohort

Abstract: Background: The reported prevalence of coeliac disease (CD) in rheumatoid arthritis (RA) is variable.

Date: 2025-01-20