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Chitinase 1: a novel therapeutic target in metabolic dysfunction-associated steatohepatitis

Abstract: Background: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by persistent inflammatory cascades, with macrophage activation playing a pivotal…

Date: 2024-09-23

Leveraging single-cell transcriptomic data to uncover immune suppressive cancer cell subsets in triple-negative canine breast cancers

Abstract: Introduction: Single-cell RNA sequencing (scRNA-seq) has become an essential tool for uncovering the complexities of various physiological and immunopathological…

Date: 2024-09-23

Medical residents’ knowledge, attitudes and practices regarding antibiotics, antimicrobial stewardship and multidrug-resistant bacteria: a cross-sectional study in a major university in Iran

Abstract: Background: Antimicrobial resistance (AMR) is one of the biggest threats to global public health systems. This study aimed to assess the knowledge, attitudes and…

Date: 2024-09-23

Distinct soluble immune checkpoint profiles characterize COVID-19 severity, mortality and SARS-CoV-2 variant infections

Abstract: Introduction: Over the past four years, the COVID-19 pandemic has posed serious global health challenges. The severe form of disease and death resulted from the failure…

Date: 2024-09-23

Patient sex and use of tranexamic acid in liver transplantation

Abstract: Background: Differences in medical treatment between women and men are common and involve out-of-hospital emergency care, the intensity of pain treatment, and the use of…

Date: 2024-09-23

Application of different CO2 pneumoperitoneum pressure in laparoscopic pyeloplasty for infants with ureteropelvic junction obstruction

Abstract: Background: Laparoscopic pyeloplasty is a minimally invasive approach for the therapy of infant ureteropelvic junction obstruction (UPJO), reliant on CO2…

Date: 2024-09-23

Negative and positive urgency as pathways in the intergenerational transmission of suicide risk in childhood

Abstract: Introduction: Parental suicide attempts and suicide death increase suicide risk in their offspring. High levels of impulsivity have been observed in families at high…

Date: 2024-09-23

Gut microbiota and functional outcome after ischemic stroke: a Mendelian randomization study

Abstract: Background: Previous studies have shown that gut microbiota dysbiosis could affect clinical prognosis through an unknown mechanism. However, the causal relationship…

Date: 2024-09-23

Prognosis of colorectal cancer, prognostic index of immunogenic cell death associated genes in response to immunotherapy, and potential therapeutic effects of ferroptosis inducers

Abstract: Introduction: This study leverages bioinformatics and medical big data to integrate datasets from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA),…

Date: 2024-09-20