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Gut-bone axis research: unveiling the impact of gut microbiota on postmenopausal osteoporosis and osteoclasts through Mendelian randomization

Abstract: Background: Postmenopausal osteoporosis is a prevalent disease that affects the bone health of middle-aged and elderly women. The link between gut microbiota and bone…

Date: 2024-05-31

Genetic link between depression and musculoskeletal disorders: insights from Mendelian randomization analysis

Abstract: Background: The association between depression and musculoskeletal diseases has long been a subject of contentious debate. However, the causal relationship between the…

Date: 2024-05-31

TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells

Abstract: Background: In early infected or severe coronavirus disease 2019 (COVID-19) patients, circulating NK cells are consistently reduced, despite being highly activated or…

Date: 2024-05-31

Insights into maternal and neonatal anti-Ro/SSA antibodies: implications on pregnancy and neonatal health

Abstract: Introduction: The presence of anti-Ro/SSA antibodies is associated with an increased risk of adverse maternal and neonatal outcomes in patients with autoimmune rheumatic…

Date: 2024-05-30

Juvenile dermatomyositis with central nervous system involvement: two case reports from a retrospective single-center cohort, with literature review

Abstract: Background: Juvenile dermatomyositis (JDM) is a systemic autoimmune disease primarily involving the muscles and skin; it can also affect the central nervous system…

Date: 2024-05-30

Effects of grit on medical students’ wellbeing during clerkships: a longitudinal observational cohort study

Abstract: Introduction: In medical education, the clerkship phase is a demanding period during which medical students learn to navigate the responsibilities of medical school and…

Date: 2024-05-30

Right ventricular fibrosis in adults with uncorrected secundum atrial septal defect and pulmonary hypertension: a cardiovascular magnetic resonance study with late gadolinium enhancement, native T1 and extracellular volume

Abstract: Introduction: Right ventricular (RV) fibrosis represents both adaptive and maladaptive responses to the overloaded RV condition. Its role in pulmonary hypertension (PH)…

Date: 2024-05-30

Mechanisms of left ventricular systolic dysfunction in light chain amyloidosis: a multiparametric cardiac MRI study

Abstract: Background: Cardiac systolic dysfunction is a poor prognostic marker in light-chain (AL) cardiomyopathy, a primary interstitial disorder; however, its pathogenesis is…

Date: 2024-05-30

Analysis of research hotspots and trends in pediatric ophthalmopathy based on 10 years of WoSCC literature

Abstract: Background: Ophthalmopathy occurring in childhood can easily lead to irreversible visual impairment, and therefore a great deal of clinical and fundamental researches…

Date: 2024-05-30