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Unraveling the genetic basis of the causal association between inflammatory cytokines and osteonecrosis

Abstract: Background: Previous studies have reported that the occurrence and development of osteonecrosis is closely associated with immune-inflammatory responses. Mendelian…

Date: 2024-04-29

Burnout among elementary and high school teachers in three Canadian provinces: prevalence and predictors

Abstract: Background: Burnout is a longstanding issue among educators and has been associated with psychological and physical health problems such as depression, and insomnia.

Date: 2024-04-26

Knowledge and attitudes about vitamin A consumption and its relationship with night blindness in university students

Abstract: Introduction: Night blindness is the first sign of vitamin A deficiency (VAD), which can lead to blindness if left untreated. University students may be at risk of…

Date: 2024-04-26

Osteomyelitis is associated with increased anti-inflammatory response and immune exhaustion

Abstract: Introduction: Osteomyelitis (OMS) is a bone infection causing bone pain and severe complications. A balanced immune response is critical to eradicate infection without…

Date: 2024-04-26

Transition to a mesenchymal state in neuroblastoma may be characterized by a high expression of GD2 and by the acquisition of immune escape from NK cells

Abstract: Background: Neuroblastoma (NB) is characterized by both adrenergic (ADRN) and undifferentiated mesenchymal (MES) subsets. The ganglioside sialic acid-containing…

Date: 2024-04-26

KIF1C and new Huntingtin-interacting protein 1 binding proteins regulate rheumatoid arthritis fibroblast-like synoviocytes’ phenotypes

Abstract: Background: Huntingtin-interacting protein-1 (HIP1) is a new arthritis severity gene implicated in the regulation of the invasive properties of rheumatoid arthritis (RA)…

Date: 2024-04-25

Comparative single-cell multiplex immunophenotyping of therapy-naive patients with rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosus shed light on disease-specific composition of the peripheral immune system

Abstract: Introduction: Systemic autoimmune diseases (SADs) are a significant burden on the healthcare system. Understanding the complexity of the peripheral immunophenotype in…

Date: 2024-04-25

Skeletal muscle index based on CT at the 12th thoracic spine level can predict osteoporosis and fracture risk: a propensity score-matched cohort study

Abstract: Background: Multiple studies have shown that skeletal muscle index (SMI) measured on abdominal computed tomography (CT) is strongly associated with bone mineral density…

Date: 2024-04-25