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Characterization of prostatic cancer lesion and gleason grade using a continuous-time random-walk diffusion model at high b-values

Abstract: Background: Distinguishing between prostatic cancer (PCa) and chronic prostatitis (CP) is sometimes challenging, and Gleason grading is strongly associated with…

Date: 2024-05-24

Effect of sustained decreases in sedentary time and increases in physical activity on liver enzymes and indices in type 2 diabetes

Abstract: Background: Current guidelines for nonalcoholic fatty liver disease (NAFLD) recommend high volumes and/or intensities of physical activity (PA), the achievement of which…

Date: 2024-05-24

Simultaneous targeting of Tim3 and A2a receptors modulates MSLN-CAR T cell antitumor function in a human cervical tumor xenograft model

Abstract: Introduction: Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of hematological malignancies. However, its efficacy in solid tumors is…

Date: 2024-05-24

Oral curcumin ameliorates acute murine campylobacteriosis

Abstract: Introduction: Human infections with the food-borne enteropathogen Campylobacter jejuni are responsible for increasing incidences of acute campylobacteriosis cases…

Date: 2024-05-24

A qualitative assessment of community perceptions and practices towards schistosomiasis prior to introduction of a potential novel treatment option for preschool-age children in Kenya

Abstract: Background: Over 50 million preschool-age children (PSAC) in Africa need treatment for schistosomiasis but are excluded due to lack of a suitable child-friendly…

Date: 2024-05-24

Comprehensive machine learning models for predicting therapeutic targets in type 2 diabetes utilizing molecular and biochemical features in rats

Abstract: Introduction: With the increasing prevalence of type 2 diabetes mellitus (T2DM), there is an urgent need to discover effective therapeutic targets for this complex…

Date: 2024-05-24

Marine microalgae Schizochytrium demonstrates strong production of essential fatty acids in various cultivation conditions, advancing dietary self-sufficiency

Abstract: Introduction: Polyunsaturated fatty acids (PUFAs) are essential nutrients that humans obtain from their diet, primarily through fish oil consumption. However, fish oil…

Date: 2024-05-24

Predictive model of suicide risk in Colombian university students: quantitative analysis of associated factors

Abstract: Introduction: The risk of suicide and completed suicides among young university students presents critical challenges to mental and public health in Colombia and…

Date: 2024-05-24

Determining diagnostic delays in Romanian multiple myeloma patients using the Aarhus statement

Abstract: Introduction: Multiple Myeloma (MM) is classified as one of the most challenging cancers to diagnose, and the hematological malignancy is associated with prolonged…

Date: 2024-05-24