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Simultaneous targeting of Tim3 and A2a receptors modulates MSLN-CAR T cell antitumor function in a human cervical tumor xenograft model

Abstract: Introduction: Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of hematological malignancies. However, its efficacy in solid tumors is…

Date: 2024-05-24

Comprehensive machine learning models for predicting therapeutic targets in type 2 diabetes utilizing molecular and biochemical features in rats

Abstract: Introduction: With the increasing prevalence of type 2 diabetes mellitus (T2DM), there is an urgent need to discover effective therapeutic targets for this complex…

Date: 2024-05-24

Characterization of prostatic cancer lesion and gleason grade using a continuous-time random-walk diffusion model at high b-values

Abstract: Background: Distinguishing between prostatic cancer (PCa) and chronic prostatitis (CP) is sometimes challenging, and Gleason grading is strongly associated with…

Date: 2024-05-24

Association of specific ACE2 and TMPRSS2 variants with circulatory cytokines of COVID-19 Emirati patients

Abstract: Introduction: The COVID-19 pandemic represented one of the most significant challenges to researchers and healthcare providers. Several factors determine the disease…

Date: 2024-05-24

A qualitative assessment of community perceptions and practices towards schistosomiasis prior to introduction of a potential novel treatment option for preschool-age children in Kenya

Abstract: Background: Over 50 million preschool-age children (PSAC) in Africa need treatment for schistosomiasis but are excluded due to lack of a suitable child-friendly…

Date: 2024-05-24

Attitudes of European psychiatrists on psychedelics: a qualitative study

Abstract: Introduction and aim: It is important to understand how mental health practitioners view recent findings on psychedelic-assisted psychotherapy (PAP) as there is…

Date: 2024-05-24

Management of iron deficiency anemia during pregnancy: a midwife-led continuity of care model

Abstract: Background: Globally, 36.5% of pregnancies are affected by anemia, particularly in low-and middle-income countries, posing significant risks to maternal and perinatal…

Date: 2024-05-24

Ovarian carcinosarcoma is highly aggressive compared to other ovarian cancer histotypes

Abstract: Background: Ovarian carcinosarcoma (OCS) is an unusual ovarian cancer type characterized by distinct carcinomatous and sarcomatous components. OCS has been excluded from…

Date: 2024-05-24

Treatment patterns in a real-world cohort of patients with Wilson disease in the United States

Abstract: Background: Wilson disease (WD) is a rare and potentially fatal genetic disorder caused by accumulation of toxic levels of copper. Current treatments include chelating…

Date: 2024-05-24

Assessing the role of advanced artificial intelligence as a tool in multidisciplinary tumor board decision-making for primary head and neck cancer cases

Abstract: Background: Head and neck squamous cell carcinoma (HNSCC) is a complex malignancy that requires a multidisciplinary approach in clinical practice, especially in tumor…

Date: 2024-05-24