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Single-cell analysis reveals the cellular and transcriptional heterogeneity of the normal pediatric thyroid

Abstract: To enhance the understanding of cellular heterogeneity within the pediatric thyroid, single-nuclei RNA sequencing was used to recover 38,069 non-pathogenic cells from…

Date: 2026-01-29

Identification of two novel MVD mutations and one novel FDPS mutation in Chinese patients with porokeratosis

Abstract: Porokeratosis (PK) is an autosomal dominant inherited disorder characterized by abnormal epidermal keratinization, primarily resulting from mutations in four genes…

Date: 2026-01-29

Standardized pressure provocation as an objective clinical marker of omalizumab response in delayed pressure urticaria: an open-label, real-life, prospective cohort

Abstract: Delayed pressure urticaria (DPU) is a disabling chronic inducible urticaria characterized by delayed painful swelling after sustained pressure. Evidence-based…

Date: 2026-01-29

Co-exposure to lead and cadmium is associated with increased severity of social deficits in children with autism spectrum disorders

Abstract: This case–control study aimed to compare micronutrient (vitamins and minerals) profiles between children with autism spectrum disorders (ASD) and age- and gender-matched…

Date: 2026-01-29

Epidemiological profile of acquired syphilis in children and adolescents in Brazil: a nationwide observational study

Abstract: Acquired syphilis, which is historically considered a condition with almost exclusive prevalence in adults, has shown, in recent evidence, an alarming increase amongst…

Date: 2026-01-29

Exploring the practices, challenges, and pathways for enhancement of grassroots social organizations in preventing child unintentional injuries: a qualitative study in Guizhou, China

Abstract: Children’s unintentional injuries represent a global public health problem. Guizhou, as an economically underdeveloped province in southwest China, faces challenges in…

Date: 2026-01-29

Identification of maturity-onset diabetes of the young through targeted next-generation sequencing in Thai patients with atypical diabetes in real-world practice

Abstract: Maturity-onset diabetes of the young (MODY) is often misdiagnosed as either autoimmune type 1 diabetes (T1D) or polygenic type 2 diabetes (T2D), resulting in missed…

Date: 2026-01-29

Long-term health effects of COVID-19 among patients in Croatian primary care settings

Abstract: The COVID-19 pandemic has left lasting effects that extend beyond the acute phase of infection, with increasing evidence of long-term health consequences. This study…

Date: 2026-01-29

The prognostic significance of JAML and its role in remodeling the immune microenvironment via the cGAS-STING pathway in endometrial cancer

Abstract: Endometrial cancer (EC) is a major gynecological malignancy with a poor prognosis in the advanced stages. Junctional adhesion molecule-like protein (JAML) is gaining…

Date: 2026-01-29

Real-world data-based assessment of therapy-related myeloid neoplasms after poly(ADP-ribose) polymerase inhibitor treatment in ovarian cancer

Abstract: Poly(ADP-ribose) polymerase inhibitors (PARPi) have significantly improved outcomes in ovarian cancer. However, therapy-related myeloid neoplasms (t-MNs) have emerged as…

Date: 2026-01-29