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Lifestyle behaviors, social and economic disadvantages, and all-cause and cardiovascular mortality: results from the US National Health Interview Survey

Abstract: Aim: To examine the independent relationships of lifestyle and social and economic factors with all-cause and cardiovascular disease (CVD) mortality in a large…

Date: 2024-03-27

IL-6 signaling drives self-renewal and alternative activation of adipose tissue macrophages

Abstract: Introduction: Obesity is associated with chronic low-grade inflammation of adipose tissue (AT) and an increase of AT macrophages (ATMs) that is linked to the onset of…

Date: 2024-03-27

Disruption of IL-17-mediated immunosurveillance in the respiratory mucosa results in invasive Streptococcus pyogenes infection

Abstract: Introduction: Streptococcus pyogenes is a Gram-positive pathogen that causes a significant global burden of skin pyoderma and pharyngitis. In some cases, infection can…

Date: 2024-03-27

Circulating miRNA-21 is an innovative biomarker for cardiovascular events in erectile dysfunction patients

Abstract: Introduction: It is well-known that circulating microRNAs (miRNAs) play a relevant role in many kinds of diseases by regulating the expression of genes involved in…

Date: 2024-03-27

The frequency and timing of sepsis-associated coagulopathy in the neonatal intensive care unit

Abstract: Introduction: Sepsis is a common cause of morbidity and mortality in the neonatal intensive care unit (NICU). The frequency and severity of sepsis-associated…

Date: 2024-03-27

The potential causal relationship between various lifestyles and depression: a univariable and multivariable Mendelian randomization study

Abstract: Background: Previous studies have shown that lifestyle was associated with depression. Thus, the aim of this study was to examine the causality between multiple…

Date: 2024-03-27

Phase 1, first-in-human study of TYRP1-TCB (RO7293583), a novel TYRP1-targeting CD3 T-cell engager, in metastatic melanoma: active drug monitoring to assess the impact of immune response on drug exposure

Abstract: Introduction: Although checkpoint inhibitors (CPIs) have improved outcomes for patients with metastatic melanoma, those progressing on CPIs have limited therapeutic…

Date: 2024-03-27