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Integrated metabolomics and transcriptomics to reveal biomarkers and mitochondrial metabolic dysregulation of premature ovarian insufficiency

Abstract: Background: The metabolic characteristics of premature ovarian insufficiency (POI), a reproductive endocrine disease characterized by abnormal sex hormone metabolism and…

Date: 2024-01-16

Inhibition of ERO1a and IDO1 improves dendritic cell infiltration into pancreatic ductal adenocarcinoma

Abstract: Introduction: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal and treatment resistant cancers. Due to its desmoplastic and hypoxic nature along with an…

Date: 2024-01-16

B-cell-specific MhcII regulates microbiota composition in a primarily IgA-independent manner

Abstract: Background: The expression of major histocompatibility complex class II (MhcII) molecules on B cells is required for the development of germinal centers (GCs) in…

Date: 2024-01-16

Interaction between triglyceride-glucose index and thyroid hormones on coronary artery disease risk in patient with euthyroid

Abstract: Background: Triglyceride-glucose (TyG) index is an effective indicator in indentifying in pre-diabetes, diabetes, and coronary artery disease (CAD). However, the value…

Date: 2024-01-16

Specific analysis of PM2.5-attributed disease burden in typical areas of Northwest China

Abstract: Background: Frequent air pollution events in Northwest China pose a serious threat to human health. However, there is a lack of specific differences assessment in…

Date: 2024-01-16

Novel DNA methylome biomarkers associated with adalimumab response in rheumatoid arthritis patients

Abstract: Background and aims: Rheumatoid arthritis (RA) patients are currently treated with biological agents mostly aimed at cytokine blockade, such as tumor necrosis…

Date: 2024-01-16

Supplementary posterior fusion in patients operated on employing TLIF may decrease the instrumentation failure rate

Abstract: Background: It is supposed that additional posterior fusion may provide additional stability of the pedicle screw; however, the clinical impact of additional posterior…

Date: 2024-01-16

Changes in body mass index and waist circumference and heart failure in type 2 diabetes mellitus

Abstract: Background: To determine the association of unintentional changes in body mass index (BMI) and waist circumference (WC) with the risk of heart failure (HF) among adults…

Date: 2024-01-16

Neurosteroid [3?,5?]-3-hydroxy-pregnan-20-one enhances IL-10 production via endosomal TRIF-dependent TLR4 signaling pathway

Abstract: Background: Previous studies demonstrated the inhibitory effect of allopregnanolone (3?,5?-THP) on the activation of inflammatory toll-like receptor 4 (TLR4) signals in…

Date: 2024-01-16