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Immunodiagnostic profiling of SPON2 and MSMB as biomarkers in prostate cancer for nanomaterial- based detection strategies

Abstract: This study aimed to validate secreted biomarkers SPON2 and MSMB with tumor-specific expression and immunogenicity for nanomaterial-based prostate cancer diagnostics.…

Date: 2025-10-22

Durvalumab following definitive chemoradiotherapy among patients with stage III NSCLC in the Thai population: a real-world, multicenter observational study

Abstract: In locally advanced non-small cell lung cancer (LA-NSCLC), durvalumab as consolidation therapy following definitive chemoradiotherapy (CRT) was established as the…

Date: 2025-10-22

Identification of immunogenic cell death signature genes in hepatocellular carcinoma: from single-cell transcriptomics to in vitro mechanistic validation and comprehensive prognostic modeling with hundreds of machine learning algorithms

Abstract: Hepatocellular carcinoma (HCC) lacks reliable prognostic biomarkers for immunotherapy. Immunogenic cell death (ICD) represents a promising therapeutic target, but its…

Date: 2025-10-22

An analysis of the distribution of bone and soft tissue sarcoma diagnoses and their disparities in Southwest Germany: a multicenter approach

Abstract: Sarcoma is a rare and highly heterogeneous family of mesenchymal tumors. The experience and interdisciplinary approach of specialized high-volume sarcoma centers has a…

Date: 2025-10-22

Residual pattern of primary tumor and lymph node in ESCC treated with nCRT with or without pembrolizumab: an analysis from a prospective cohort

Abstract: Neoadjuvant chemoradiotherapy (nCRT) is recommended as the standard of care for locally advanced esophageal squamous cell carcinoma (ESCC). Adding immunotherapy to nCRT…

Date: 2025-10-22

Comparative impact of supine vs prone positioning on dose distribution, acute toxicity, and setup error in postoperative radiotherapy for cervical cancer: a multidimensional propensity-matched cohort study

Abstract: Postoperative radiotherapy is standard for high-risk cervical cancer, but acute toxicities—particularly gastrointestinal and hematologic—remain clinically relevant.…

Date: 2025-10-22

Short-term outcomes of non-ST segment elevation acute coronary syndrome after percutaneous coronary intervention: a single-center speckle tracking echocardiographic study in Vietnam

Abstract: Data on the prognostic value of myocardial strain in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) from low- and middle-income countries…

Date: 2025-10-22

Integrative multi-omics identifies MEIS3 as a diagnostic biomarker and immune modulator in hypertrophic cardiomyopathy

Abstract: Hypertrophic cardiomyopathy (HCM) is a prevalent genetic cardiac disorder characterized by myocardial hypertrophy and diastolic dysfunction. While traditionally…

Date: 2025-10-22

Non-invasive PECS model for detection of combined post-capillary pulmonary hypertension

Abstract: Combined post-capillary pulmonary hypertension (Cpc-PH) is a severe form of pulmonary hypertension associated with high morbidity and mortality. Early identification and…

Date: 2025-10-22

Evaluating the effectiveness of integrated care in targeted therapy for patients with chronic lymphocytic leukemia

Abstract: For patients with chronic lymphocytic leukemia (CLL), the type of nursing care during targeted therapy may significantly impact treatment efficacy and quality of life.…

Date: 2025-10-21