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Total flavonoids from Abelmoschus manihot (L.) improve diabetes nephropathy by regulating the gut–kidney axis

Abstract: A recent clinical study demonstrated that Huangkui capsule (with its bioactive constituents being total flavones extracted from Abelmoschus manihot (L.), TFA) combined…

Date: 2026-01-28

Association between metabolic dysfunction-associated fatty liver disease and cardiovascular autonomic neuropathy in type 2 diabetes

Abstract: This cross-sectional study aimed to elucidate the relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and diabetic cardiovascular autonomic…

Date: 2026-01-28

Anatomical evidence links the stomach to the central amygdala, a region responsive to local GLP-1R agonist induced feeding and nausea-like behaviors in male mice

Abstract: The glucagon-like peptide-1 receptor (GLP-1R) agonist liraglutide is an effective therapeutic agent for obesity, primarily through its ability to suppress appetite and…

Date: 2026-01-28

Exploring the gut microbiome in type 2 diabetes across different insulin resistance levels: a machine learning approach

Abstract: Insulin resistance (IR) is central to type 2 diabetes mellitus (T2DM). Composite indices including the atherogenic index of plasma (AIP), metabolic score for insulin…

Date: 2026-01-28

Integrated multi-platform metabolomics reveals fatty acid-mediated inflammatory signatures in pretibial myxedema

Abstract: Pretibial myxedema (PTM) is a refractory autoimmune dermopathy associated with Graves’ disease. Although metabolic dysregulation has been recognized in…

Date: 2026-01-28

Inactivation of cofilin-1 in Mcpt5-Cre-nf-Cfl1 fl/fl mice prevents the formation of connective tissue mast cells without affecting basophils: a new tool to investigate the specific role of CTMCs in disease

Abstract: Actin-binding proteins play a critical role in regulating the dynamic rearrangement of the actin cytoskeleton, which is essential for maintaining cellular homeostasis…

Date: 2026-01-28

Construction of a nomogram model for predicting vaginal birth after induction of labor in pregnant women with fetal growth restriction at term

Abstract: The study aimed to develop and validate a predictive nomogram model of vaginal delivery in women with fetal growth restriction (FGR) who undergo labor induction. A…

Date: 2026-01-28

KCNB1 mutation impairs neuronal differentiation by disrupting gene expression temporal regulation and neuron-specific pathways

Abstract: This study aims to rigorously evaluate the consistency and reliability of a pluripotent stem cell (PSC) differentiation system and explore how the KCNB1 mutation…

Date: 2026-01-28

Effect of timely diagnosis and treatment on growth and body proportionality of children with congenital hypothyroidism

Abstract: Congenital hypothyroidism (CH) is a preventable cause of growth and neurodevelopmental deficits. In India, lack of universal newborn screening (NBS) delays diagnosis.…

Date: 2026-01-28

Trends and projections of dermatitis burden (1990–2040): a 2021 global burden of disease analysis

Abstract: Dermatitis is a major global public health challenge. This study evaluates its burden from 1990 to 2021 and projects future burden over the next 20?years. Data from the…

Date: 2026-01-28