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Aerobic exercise improves BKCa channel-mediated vasodilation in diabetic vascular smooth muscle via AMPK/Nrf2/HO-1 pathway

Abstract: This study aims to investigate the effect of aerobic exercise training on BKCa channel in diabetic vascular smooth muscle and explore the underlying mechanism.

Date: 2023-12-02

Validation of non-invasive indicators in the screening of metabolic dysfunction-associated fatty liver disease: a cross-sectional study among Uighurs in rural Xinjiang

Abstract: Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common chronic liver disease in China. Our study aimed to evaluate the screening value of the…

Date: 2023-12-02

Overcrowding in emergency departments: an overview of reviews describing global solutions and their outcomes

Abstract: Emergency Department (ED) crowding is defined as a situation wherein the demands of emergency services overcome the ability of a department to provide high-quality care…

Date: 2023-12-02

Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease

Abstract: Disease-related stress can trigger the occurrence of herpes zoster (HZ). Fatty liver disease (FLD) can have adverse effects on the human body and may induce stress in…

Date: 2023-12-02

Prenatal exposure to per- and polyfluoroalkyl substances and early childhood adiposity and cardiometabolic health in the Healthy Start study

Abstract: Observational and experimental studies have suggested that prenatal exposure to per- and polyfluoroalkyl substances (PFAS) can increase childhood adiposity and…

Date: 2023-12-02

Epigenetic programming for obesity and noncommunicable disease: From womb to tomb

Abstract: Several epidemiological, clinical and experimental studies in recent decades have shown the relationship between exposure to stressors during development and health…

Date: 2023-12-02

Conversions between metabolically unhealthy and healthy obesity from midlife to late-life

Abstract: Metabolically healthy obesity may be a transient phenotype, but studies with long follow-up, especially covering late-life, are lacking. We describe conversions between…

Date: 2023-12-02

New insights in thyroid diagnosis and treatment

Abstract: The prevalence of thyroid disease continues to rise. As a consequence, the research in the thyroid field has significantly increased over time. Thus, clinicians, and…

Date: 2023-12-02

Bioequivalence Study of Two Tablet Formulations of Clonazepam 2 mg: A Randomized, Open-Label, Crossover Study in Healthy Mexican Volunteers Under Fasting Conditions

Abstract: The prevalence of neurological disorders is high among the Mexican population. Clonazepam is primarily indicated to treat panic disorders, certain kinds of epilepsy such…

Date: 2023-12-02

Comparison of the Incidence of Adverse Events Between Japanese and Non-Japanese Healthy Subjects in Phase I Studies: A Systematic Review and Meta-Analysis

Abstract: Ethnic and racial differences are key factors affecting the results of clinical studies. However, the influence of these factors on the efficacy and safety of medicinal…

Date: 2023-12-02