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Estimating the cost and epidemiology of mild to severe chronic pain associated with osteoarthritis in England: a retrospective analysis of linked primary and secondary care data

Abstract: Objective Osteoarthritis (OA) affects 10% of adults in the UK. Despite over one-third of people with OA experiencing chronic pain, few studies have examined the…

Date: 2023-11-29

Development of a microcosting protocol to determine the economic cost of diagnostic genomic testing for rare diseases in Australia

Abstract: Introduction Genomic testing is a relatively new, disruptive and complex health technology with multiple clinical applications in rare diseases, cancer and infection…

Date: 2023-11-29

REstrictive versus StandarD FlUid Management in Mechanically Ventilated ChildrEn Admitted to PICU: study protocol for a pilot randomised controlled trial (REDUCE-1)

Abstract: Introduction Intravenous fluid therapy is the most common intervention in critically ill children. There is an increasing body of evidence questioning the safety of…

Date: 2023-11-29

Knowledge, attitude and practices towards SARS-CoV-2 genetic mutations and emerging variants among the population in Bangladesh: a cross-sectional study

Abstract: Objectives The coronavirus is continuously mutating and creating new SARS-CoV-2 variants. Public awareness about SARS-CoV-2 mutation is essential for effective…

Date: 2023-11-29

Feasibility and acceptability of using the Alarm Distress BaBy (ADBB) scale within universal health visiting practice in England: a mixed-methods study protocol

Abstract: Introduction The Alarm Distress BaBy (ADBB) scale developed by Guedeney and Fermanian in 2001, is a validated screening tool designed for use by healthcare practitioners…

Date: 2023-11-29

Peptidylarginine deiminase 2 citrullinates MZB1 and promotes the secretion of IgM and IgA

Abstract: Introduction: MZB1 is an endoplasmic reticulum residential protein preferentially expressed in plasma cells, marginal zone and B1 B cells. Recent studies on murine B…

Date: 2023-11-29

Facing Pediatric Rheumatic Diseases: The Role of Disease Activity and Parental Emotion Regulation Strategy in Parents’ and Children’s Psychological Adjustment

Abstract: Background: Pediatric rheumatic diseases (PRDs) are a group of chronic disorders that start in childhood and are characterized by periodic exacerbations and remissions…

Date: 2023-11-28

Motor Development in Children with Cerebral Palsy in Sweden—A Population-Based Longitudinal Register Study

Abstract: The aim was to explore longitudinal motor development in children with cerebral palsy (CP) in Sweden with respect to the Gross Motor Function Classification System…

Date: 2023-11-28

In Silico Structural Protein Evaluation of the Phenylalanine Hydroxylase p.(Tyr77His) Variant Associated with Benign Hyperphenylalaninemia as Identified through Mexican Newborn Screening

Abstract: Hyperphenylalaninemia (HPA), which includes phenylketonuria (PKU), is a genetic autosomal recessive disorder arising from a deficiency in the enzyme named phenylalanine…

Date: 2023-11-28

Testing a Home Solution for Preparing Young Children for an Awake MRI: A Promising Smartphone Application

Abstract: Thanks to its non-invasive nature and high-resolution imaging capabilities, magnetic resonance imaging (MRI) is a valuable diagnostic tool for pediatric patients.…

Date: 2023-11-28