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The frequency and timing of sepsis-associated coagulopathy in the neonatal intensive care unit

Abstract: Introduction: Sepsis is a common cause of morbidity and mortality in the neonatal intensive care unit (NICU). The frequency and severity of sepsis-associated…

Date: 2024-03-27

The potential causal relationship between various lifestyles and depression: a univariable and multivariable Mendelian randomization study

Abstract: Background: Previous studies have shown that lifestyle was associated with depression. Thus, the aim of this study was to examine the causality between multiple…

Date: 2024-03-27

Phase 1, first-in-human study of TYRP1-TCB (RO7293583), a novel TYRP1-targeting CD3 T-cell engager, in metastatic melanoma: active drug monitoring to assess the impact of immune response on drug exposure

Abstract: Introduction: Although checkpoint inhibitors (CPIs) have improved outcomes for patients with metastatic melanoma, those progressing on CPIs have limited therapeutic…

Date: 2024-03-27

Shifting paradigms: a pivotal study on laparoscopic resection for colovesical fistulas in diverticular disease

Abstract: Background: Colovesical fistulas (CVFs) pose a challenge in diverticulitis, affecting 4% to 20% of sigmoid colon cases. Complicated diverticular disease contributes…

Date: 2024-03-27

BmSPP is a virus resistance gene in Bombyx mori

Abstract: Introduction: Signal peptide peptidase (SPP) is an intramembrane protease involved in a variety of biological processes, it participates in the processing of signal…

Date: 2024-03-27

Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency

Abstract: Introduction: Exosome-enriched small extracellular vesicles (sEVs) are nanosized organelles known to participate in long distance communication between cells, including…

Date: 2024-03-27

Antibody dependent cellular cytotoxicity-inducing anti-EGFR antibodies as effective therapeutic option for cutaneous melanoma resistant to BRAF inhibitors

Abstract: Introduction: About 50% of cutaneous melanoma (CM) patients present activating BRAF mutations that can be effectively targeted by BRAF inhibitors (BRAFi). However, 20%…

Date: 2024-03-27

Cigarette smoking and mammographic breast density in post-menopausal women from the EPIC Florence cohort

Abstract: Introduction: Cigarette smoking has been recognized as a risk factor for breast cancer (BC) also if the biological mechanism remains poorly understood. High mammographic…

Date: 2024-03-27