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Tranexamic acid in patients with post-traumatic elbow stiffness: protocol for a randomised, double-blind, placebo-controlled trial investigating the effectiveness of tranexamic acid at reducing the recurrence of heterotopic ossification after open elbow arthrolysis

Abstract: Introduction Exaggerated inflammatory response is one of the main mechanisms underlying heterotopic ossification (HO). It has been suggested that the antifibrinolytic…

Date: 2023-12-18

Defining ‘therapeutic value’ of medicines: a scoping review

Abstract: Objectives In recent years, discussions on the importance and scope of therapeutic value of new medicines have intensified, stimulated by the increase of prices and…

Date: 2023-12-18

Prognostic value of acute National Institutes of Health Stroke Scale Items on disability: a registry study of first-ever stroke in the western part of Sweden

Abstract: Objectives We aimed to study how the individual items of the National Institutes of Health Stroke Scale (NIHSS) at admission predict functional independence 3 months…

Date: 2023-12-18

Optimal treatment of asymptomatic patients with severe aortic stenosis: protocol of a prospective, multicentre, registry study

Abstract: Introduction Decisions regarding the optimal timing of intervention for asymptomatic aortic stenosis (AS) are controversial. The study aims to identify potential risk…

Date: 2023-12-18

New methodology to assess the excess burden of antibiotic resistance using country-specific parameters: a case study regarding E. coli urinary tract infections

Abstract: Objectives Antimicrobial resistant (AMR) infections are a major public health problem and the burden on population level is not yet clear. We developed a method to…

Date: 2023-12-18

Comparing the long-term outcomes in chronic coronary syndrome patients with prior ST-segment and non-ST-segment elevation myocardial infarction: findings from the TIGRIS registry

Abstract: Objectives Compared with ST-segment elevation myocardial infarction (STEMI) patients, non-STEMI (NSTEMI) patients have more comorbidities and extensive coronary artery…

Date: 2023-12-18

Shared decision-making improving efficacy in diarrhoea-dominant irritable bowel syndrome in Chinese outpatient setting: protocol of a prospective, randomised controlled trial

Abstract: Introduction Diarrhoea-dominant irritable bowel syndrome (IBS-D) is a disorder with multiple pathogenesis; many people with IBS-D may have psychosocial issues which can…

Date: 2023-12-18

Study protocol for Care cOORDInatioN And sympTom managEment (COORDINATE) programme: a feasibility study

Abstract: Introduction Sustainable approaches to support care coordination and symptom management needs of critically ill adults living with multimorbidity are needed to combat…

Date: 2023-12-18

Exploring perceptions and operational considerations for use of a smartphone application to self-monitor blood pressure in pregnancy in Lombok, Indonesia: protocol for a qualitative study

Abstract: Introduction Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal deaths globally and require close monitoring of blood pressure (BP) to mitigate…

Date: 2023-12-18

Cohort study to characterise surgical site infections after open surgery in the UK’s National Health Service

Abstract: Objective To characterise surgical site infections (SSIs) after open surgery in the UK’s National Health Service. Design Retrospective cohort analysis of electronic…

Date: 2023-12-18