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Global, regional and national cancer burden and trends of middle-aged and older populations: a GBD 2021-based analysis, prediction and prevention

Abstract: Middle-aged and older adults (MAOs; defined as individuals aged ?40 years) account for the global cancer burden, contributing to 70–80% of cases. Characterizing cancer…

Date: 2026-10-07

Relevance between patients’ clinical factors and 4D-CT lung ventilation heterogeneity for evaluating the adoption of functional avoidance thoracic radiotherapy with a large patient database

Abstract: Four-dimensional computed tomography (4D-CT)-guided functional-avoidance radiotherapy reduces radiation pneumonitis, but the lack of patient selection criteria limits…

Date: 2026-10-07

Ventricular arrhythmic burden before and after mitral valve repair in mitral valve prolapse: the role of mitral annular disjunction

Abstract: Mitral valve prolapse (MVP) is increasingly recognized as an arrhythmogenic condition, with a subset of patients exhibiting ventricular arrhythmias beyond the…

Date: 2026-10-07

Associations of insulin resistance-related metabolic indices with albuminuria in primary hypertension without diabetes: a retrospective cross-sectional study

Abstract: Insulin resistance-related metabolic indices have been associated with albuminuria in general populations and in patients with diabetes, but evidence in patients with…

Date: 2026-10-07

Integrating transcriptomic analysis and experimental validation unravels autophagy- and lactylation-related gene signatures in acute myocardial infarction

Abstract: Acute myocardial infarction (AMI) is a leading global health burden. While autophagy and lactylation are crucial in cardiovascular pathophysiology, their coordinated…

Date: 2026-10-07

Association between adverse pregnancy outcomes and long-term postpartum blood pressure trajectories: a community-based cohort study

Abstract: Adverse pregnancy outcomes (APOs) increase the future risk of hypertension, but their impact on long-term postpartum blood pressure (BP) trajectories remains unclear. We…

Date: 2026-10-07

Trajectories of kinesiophobia over the first six months after cardiac pacemaker or defibrillator implantation: clinical, psychological, and rehabilitation predictors and their relation to functional capacity

Abstract: Kinesiophobia, an excessive fear of physical movement, is common after implantation of a cardiac pacemaker or implantable cardioverter defibrillator and may limit…

Date: 2026-10-07

Extent of posterior wall lesion following pulmonary vein isolation with pentaspline pulsed field and cryoballoon ablation: the potential role of deployment technique

Abstract: Pulmonary vein isolation (PVI) using cryoballoon (CB) or pulsed field ablation (PFA) with a pentaspline catheter achieves similar efficacy in atrial fibrillation (AF),…

Date: 2026-10-07

Association of clonal hematopoiesis of indeterminate potential with cardiovascular mortality in cardiovascular-kidney-metabolic syndrome: a large prospective cohort study

Abstract: Cardiovascular-kidney-metabolic (CKM) syndrome represents a progressive pathophysiological continuum. While clonal hematopoiesis of indeterminate potential (CHIP) is…

Date: 2026-10-07

Gastric involvement in multiple myeloma-associated AL amyloidosis: a case with serial endoscopy and a pooled analysis of 30 published cases

Abstract: To describe serial endoscopic findings in a patient with relapsed/refractory multiple myeloma (MM) and gastric amyloidosis and to summarize 30 published cases, with…

Date: 2026-10-06