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Transcriptomics-guided serum podoplanin and interpretable machine learning for early risk stratification of necrotizing enterocolitis in preterm infants

Abstract: To evaluate podoplanin (PDPN) as a circulating biomarker for early necrotizing enterocolitis (NEC) risk stratification and to determine whether an interpretable…

Date: 2026-10-06

Flow cytometric profiling of water buffalo milk EVs: how lactation stage drives phenotypic evolution and macrophage modulation

Abstract: Milk is more than a traditional nutrient source; it serves as a crucial carrier for milk-derived extracellular vesicles (mEVs), food-derived nanoparticles with diverse…

Date: 2026-10-06

A predictive model based on maternal immune-inflammatory markers for ARDS identification in mechanically ventilated late-preterm and term neonates

Abstract: To develop and internally evaluate a model that uses maternal blood markers obtained before delivery to differentiate neonatal acute respiratory distress syndrome (ARDS)…

Date: 2026-10-06

APASL-ACLF without previous decompensation is immunologically distinct from EASL-CLIF-ACLF with previous decompensation

Abstract: Definitions of acute-on-chronic liver failure (ACLF) differ, with a focus on extrahepatic organ failures on the basis of previously compensated or decompensated…

Date: 2026-10-06

Integrating 72-h BUN/Cr trajectories with interpretable machine learning for 28-day mortality after acute stroke: a dual-center landmark study

Abstract: The blood urea nitrogen-to-creatinine ratio (BUN/Cr) may reflect renal perfusion and systemic stress, but its early course after acute stroke is unclear. We identified…

Date: 2026-10-06

Multimodal neuroimmune diagnostic profiling for pediatric lower urinary tract dysfunction associated with occult sacral nerve abnormalities

Abstract: Persistent pediatric lower urinary tract dysfunction (LUTD) may be associated with occult sacral neural impairment, a clinically challenging condition characterized by…

Date: 2026-10-06

A Zap70 gain-of-function mutation alters mouse thymic maturation

Abstract: The tyrosine kinase ZAP-70 is essential for T-cell activation and development, but the mechanisms regulating its activity remain unclear. Previous studies showed that…

Date: 2026-10-06

Macro-micro dynamics of child undernutrition in Pakistan: a structural learning-based Bayesian network analysis of household and policy drivers

Abstract: Child undernutrition remains a major public health concern and creates health-related inequalities in developing countries, with long-term consequences for human…

Date: 2026-10-06

Rethinking networks through relatedness - a qualitative study among inpatients in forensic psychiatry

Abstract: Recovery-oriented approaches in forensic psychiatry increasingly emphasize the importance of social relationships. However, research and practice have primarily…

Date: 2026-10-06

Lion Hearts: applying implementation mapping to plan the delivery of a family-based physical activity intervention in community CrossFit affiliates

Abstract: Community-based physical activity interventions face challenges in adoption, implementation, and sustainability. Lion Hearts is a family-based physical activity…

Date: 2026-10-06