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Acyl-CoA synthetase long-chain family member 4—A novel prognostic marker in cutaneous melanoma

Abstract: Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation. Acyl coenzyme A (Acyl-CoA) synthetase long-chain family member 4 (ACSL4)…

Date: 2026-03-16

The mediating role of sleep quality in the association between inflammatory disease activity and health-related quality of life in rheumatoid arthritis

Abstract: Sleep disturbance is highly prevalent in rheumatoid arthritis (RA) and is a key determinant of patient-reported outcomes. However, the mechanistic pathways linking…

Date: 2026-03-16

Elevated stress hyperglycemia ratio predicts intensive care unit admission after surgery for gastrointestinal tumors: an INSPIRE database analysis

Abstract: Gastrointestinal tumors are a major global health burden, with surgery as the main curative treatment. The Stress Hyperglycemia Ratio (SHR) has prognostic value in…

Date: 2026-03-16

The impact of liposomal bupivacaine erector spinae plane block on postoperative analgesia and early functional recovery in patients undergoing thoracoscopic lung cancer surgery

Abstract: This study aimed to evaluate the impact of liposomal bupivacaine erector spinae plane block (ESPB) on postoperative analgesia and early functional recovery in patients…

Date: 2026-03-16

The role of anesthesia in TKA length of stay: a data-driven analysis using Boruta algorithm

Abstract: Optimizing the length of hospital stay (LOHS) after total knee arthroplasty (TKA) is essential for improving healthcare efficiency. The effect of anesthesia method on…

Date: 2026-03-16

Association of elevated circulating GDF15 and risk in acute retinal artery occlusion

Abstract: We aimed to investigate the association between circulating growth differentiation factor-15 (GDF15) levels and retinal artery occlusion (RAO), and to assess the…

Date: 2026-03-16

Catalpol mitigates rheumatoid arthritis by targeting neutrophil extracellular trap release

Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent synovial inflammation, progressive joint damage, and systemic manifestations.…

Date: 2026-03-16

A blood-biomarker based CTC-ALRI score predicts recurrence in hepatocellular carcinoma patients following curative resection

Abstract: Hepatocellular carcinoma (HCC) recurrence after curative resection remains a critical challenge that significantly compromises long-term survival. This study aimed to…

Date: 2026-03-16

A model combining nocturnal baseline impedance, post-reflux swallow-induced peristaltic wave, and acid exposure time enhances prediction of proton pump inhibitor response for extraesophageal symptoms in a Chinese population

Abstract: Gastroesophageal reflux disease(GERD) with extraoesophageal symptoms tends to respond poorly to proton pump inhibitors (PPIs). This study aimed to evaluate the role of…

Date: 2026-03-16

The gut microbiota and plasma metabolites on functional dyspepsia: a study integrating Mendelian randomization and experimental validation

Abstract: This two-sample Mendelian randomization (MR) investigation aimed to explore how gut microbiota influences functional dyspepsia (FD) via plasma metabolites. The results…

Date: 2026-03-16