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Comparative prognostic analysis of allogeneic hematopoietic stem cell transplantation regimens in the treatment of severe aplastic anemia

Abstract: Severe aplastic anemia (SAA) is a fatal bone marrow failure disorder. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the definitive curative treatment…

Date: 2026-10-05

Investigating risk factors and developing a predictive model for venous thromboembolism in patients with sepsis

Abstract: Patients with sepsis are at high risk for venous thromboembolism (VTE). However, existing assessment tools designed for general medical or surgical populations may…

Date: 2026-10-05

Long-term clinical outcomes in females with precocious puberty treated with gonadotropin-releasing hormone analogues

Abstract: To evaluate long-term anthropometric, metabolic, reproductive, and bone mineral density (BMD) outcomes in girls with central precocious puberty (CPP) treated with…

Date: 2026-10-05

Cardiovascular risk factors in autoimmune thyroiditis: role of adiponectin, resistin, inflammation and auto-immunity - a cross-sectional study

Abstract: Autoimmune thyroiditis (AIT) has been associated with an increased cardiovascular risk. Whether adipokines, inflammation and auto-immunity contribute to this increased…

Date: 2026-10-05

Machine learning-derived R-loop-related diagnostic signature for psoriasis: a multi-cohort and single-cell validation study

Abstract: Psoriasis is a chronic inflammatory skin disease characterized by dysregulated immune responses and keratinocyte (KC) hyperproliferation. Although therapeutic strategies…

Date: 2026-10-05

FeNO may serve as a noninvasive screening tool for gastroesophageal reflux disease in children under 5 years: a retrospective study

Abstract: To investigate the correlation between fractional exhaled nitric oxide (FeNO) measurement and pediatric gastroesophageal reflux disease (GERD), explore potential…

Date: 2026-10-05

Disseminated BCG disease and recurrent pulmonary infections in a child with trisomy 21 carrying a novel BACH2 variant of uncertain significance: a 5-year case report

Abstract: Trisomy 21 is associated with combined immune dysregulation, including lymphopenia, impaired responses to vaccines, and heightened susceptibility to respiratory…

Date: 2026-10-05

Serum 25-hydroxyvitamin D, systemic immune-inflammation index, and atherogenic index of plasma in statin-untreated type 2 diabetes: a cross-sectional mediation analysis

Abstract: This cross-sectional study investigated the associations between serum 25-hydroxyvitamin D [25(OH)D] levels, systemic inflammatory burden, and atherogenic lipid profile…

Date: 2026-10-05

Development and internal validation of a CatBoost–SHAP-guided nomogram for significant liver fibrosis in children with chronic hepatitis B

Abstract: Significant liver fibrosis can develop in children with chronic hepatitis B (CHB), yet liver biopsy is invasive and unsuitable for repeated assessment. We developed an…

Date: 2026-10-05

Blood pressure changes after stair climbing in busy and quiet outpatient clinic environments among Tanzanian adults: a randomised crossover study

Abstract: Blood pressure (BP) measured soon after activity may differ from later seated readings. We examined serial BP changes after stair climbing in busy and quiet outpatient…

Date: 2026-10-05