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Is painless colonoscopy associated with trainee learning? A single-center study of insertion speed and adenoma detection curves in 1,769 procedures

Abstract: To compare the learning curves of cecal intubation time and adenoma detection rate (ADR) between painless (sedated) and conventional (non-sedated) colonoscopy performed…

Date: 2026-10-05

The application of Chicago classification 4.0 in esophageal motility disorders of scleroderma: a case-control study in China

Abstract: Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease characterized by multi-organ fibrosis and vasculopathy that frequently involves the esophagus.…

Date: 2026-10-05

Nutritional status, health literacy, and lifestyle factors associated with health-related quality of life in patients with decompensated cirrhosis: a cross-sectional study

Abstract: Liver cirrhosis is one of the leading causes of liver-related mortality worldwide. The disease typically progresses from an initially asymptomatic, compensated phase to…

Date: 2026-10-05

Integrated genetic and functional analyses reveal the pathogenic effects of a novel STXBP3 variant in very-early-onset inflammatory bowel disease with immunodeficiency

Abstract: Very early onset inflammatory bowel disease (VEOIBD) is frequently driven by monogenic defects. Pathogenic variants in the syntaxin-binding protein 3 ( STXBP3 ) gene…

Date: 2026-10-05

Sex-stratified association between systemic immune-inflammation index and gallstone risk: a cross-sectional study in a Chinese adult population

Abstract: Gallstone disease is a prevalent biliary condition with rising incidence in China, driven by changes in lifestyle, metabolism, and inflammation. The systemic…

Date: 2026-10-05

Admission C-reactive protein-to-albumin ratio and serum creatinine in relation to in-hospital mortality in non-HIV tuberculous meningitis: a retrospective cohort study

Abstract: The independent and joint associations of admission C-reactive protein-to-albumin ratio (CAR) and serum creatinine with mortality in tuberculous meningitis (TBM) remain…

Date: 2026-10-05

Restlessness in cluster headache: unveiling the role of its key associations and clinical implications from a cohort study

Abstract: ICHD-3 recognizes restlessness/agitation as an accompanying feature of cluster headache (CH). However, its phenotypic significance within CH remains uncertain. We…

Date: 2026-10-05

Simple renal cysts are associated with ischemic stroke in young adults: a case–control study

Abstract: The incidence of ischemic stroke among young patients is increasing, and ischemic stroke has become a major cause of death and disability in young adults. The key to…

Date: 2026-10-05

Soluble TIM-3 and galectin-9 in cerebrospinal fluid are associated with disability at 6 months in aquaporin-4 IgG-positive neuromyelitis optica spectrum disorder

Abstract: Neuromyelitis optica spectrum disorders (NMOSD) are severe autoimmune diseases of the central nervous system characterized by autoantibodies against aquaporin 4…

Date: 2026-10-05

Longitudinal dynamics of serum neurofilament light chain and prognostic value for functional outcome after acute stroke: a prospective cohort study

Abstract: Serum neurofilament light chain (sNfL) is a blood biomarker of neuroaxonal injury, but its early longitudinal dynamics and prognostic value in clinically heterogeneous…

Date: 2026-10-05