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Early high-dose intravenous methylprednisolone is associated with faster symptom improvement in persistent ocular myasthenia gravis: a single-center retrospective study

Abstract: High-dose intravenous methylprednisolone pulse therapy (HMP) may provide rapid symptom relief in ocular myasthenia gravis (MG), but the clinical impact of its early use…

Date: 2026-10-01

Identification of Akkermansia muciniphila as a candidate gut commensal involved in the pathogenesis of rheumatoid arthritis

Abstract: The “mucosal origins hypothesis” posits that mucosal sites, such as the gut, are initial sites where immune responses first develop that may, months to years later,…

Date: 2026-10-01

Anti?PD?1/CTLA?4 bispecific antibody?based combination therapy for cervical cancer: a multicenter study with biomarker analysis

Abstract: Cadonilimab is a PD?1/CTLA?4 bispecific antibody with robust activity in platinum?pretreated advanced cervical cancer, while its first?line value and resistance…

Date: 2026-10-01

Peptide optimization to improve antigen presentation and antitumor responses in sarcoma

Abstract: Sarcomas are rare and heterogeneous malignancies for which therapeutic options remain limited, particularly in advanced disease. Standard treatments, including surgery,…

Date: 2026-10-01

Systemic immune activation coexists with compartment-specific regulatory enrichment in matched blood, peritumor, and tumor tissue from advanced oral squamous cell carcinoma

Abstract: Oral squamous cell carcinoma (OSCC) is the most prevalent form of oral cancer and is characterized by a poor prognosis and frequent immune evasion. While the tumor…

Date: 2026-10-01

Screening of risk factors and construction of a prediction model for enteral nutrition intolerance in elderly patients with comorbidities and sarcopenia

Abstract: To screen the independent risk factors for enteral nutrition intolerance (ENI) in elderly comorbid patients with sarcopenia, and to establish and validate a clinical…

Date: 2026-10-01

Identification of a novel inflammatory mast cell subpopulation in triple-negative breast cancer

Abstract: Triple-negative breast cancer (TNBC) is associated with poor therapeutic outcomes, and increasing attention has been directed toward the tumor microenvironment (TME).…

Date: 2026-10-01

Disproportionality analysis of adverse event reporting with aspirin, statins, and their co-exposure in FAERS, 2004–2025

Abstract: To characterize and compare adverse-event reporting patterns for aspirin without statins, statins without aspirin, and aspirin–statin co-exposure in the FDA Adverse…

Date: 2026-10-01

Cytokine-induced killer cells combined with temozolomide suppress glioblastoma progression in an orthotopic model and demonstrate clinical feasibility in recurrent glioblastoma

Abstract: Glioblastoma (GBM) remains an aggressive primary brain tumor with limited therapeutic options after recurrence. Cytokine-induced killer (CIK) cells are ex vivo-expanded…

Date: 2026-09-30

Fusion-specific co-mutational architecture and treatment-response associations in pediatric core-binding factor acute myeloid leukemia: a multicenter exome-profiled cohort

Abstract: Core-binding factor acute myeloid leukemia (CBF-AML) is defined by one of two founding fusions, but cooperating lesions may differ between fusion subtypes. We…

Date: 2026-09-30