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MiRNA-140-3p affects the proliferation and metastasis of osteosarcoma via the UBE2C/PI3K-Akt axis

Abstract: The data of scRNA-seq in specific databases were analyzed by bioinformatics. The expression level of miR-140-3p in osteosarcoma cells was detected using qRT-PCR, and the…

Date: 2026-07-29

Composite inflammatory biomarkers for predicting vascular crisis after finger replantation: a two-center retrospective study identifying a promising inflammatory biomarker and its multidimensional evaluation

Abstract: Vascular crisis is a leading cause of replantation failure following finger replantation, and preoperative identification of high-risk patients is essential for…

Date: 2026-07-29

A machine-learning model for staging autoimmune gastritis based on endoscopic and serological features

Abstract: Autoimmune gastritis (AIG) lacks a unified, practical staging system. The AIG-atrophic stage (AIG-AS) scheme, based on the proportional area of remnant oxyntic mucosa…

Date: 2026-07-29

Association of fluid balance trajectories and cumulative fluid balance with in-hospital mortality in patients with acute pancreatitis

Abstract: Fluid resuscitation represents a cornerstone of early management in acute pancreatitis (AP). Accumulating evidence suggests that positive fluid balance (FB) is…

Date: 2026-07-29

Effectiveness and safety of sumatriptan 85 mg/naproxen sodium 500 mg combination for acute migraine: prospective real-world evidence from the GRASP Study Group

Abstract: This prospective multicenter observational study, designed by the Greek Research Alliance for the Study of Headache and Pain (GRASP), evaluated the real-world…

Date: 2026-07-29

Enhancing long-term knowledge retention in undergraduate stroke education through virtual simulation: a randomized study

Abstract: Virtual simulation is increasingly used in undergraduate medical education, but its value for long-term retention in stroke teaching remains unclear. This trial compared…

Date: 2026-07-29

White matter lesions in migraine: a single-center retrospective study of prevalence and risk factors

Abstract: Migraine is ranked as the third most common and second most disabling neurological disorder worldwide. Neuroimaging studies demonstrate higher white matter lesion (WML)…

Date: 2026-07-29

Lamotrigine prophylaxis is associated with reduced aura frequency in patients with burdensome migraine aura: a retrospective observational study

Abstract: Migraine aura affects approximately one-third of migraine patients. In some individuals, aura remains highly disabling due to the lack of effective, targeted treatment…

Date: 2026-07-29

Diffusion microstructure alterations in subcortical gray matter are associated with cognitive and motor performance in Parkinson’s disease: a pilot study

Abstract: The cholinergic basal forebrain and subcortical gray matter have previously been implicated in Parkinson’s disease (PD), but the relationship between the symptomology of…

Date: 2026-07-29

The effectiveness of an integrated CBL and BOPPPS model in neurological nursing clinical teaching: a comparative study

Abstract: This study aimed to develop an integrated teaching plan that combines case-based learning (CBL) with the BOPPPS teaching model, its application effect in clinical…

Date: 2026-07-29