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Unveiling the aging-immune axis in irritable bowel syndrome: a multi-omics and machine learning approach to biomarker discovery and validation

Abstract: Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder with an elusive pathophysiology. Although immune dysregulation and mild mucosal…

Date: 2026-07-22

FreqMamba-Net: a frequency-enhanced state space model for fine-grained mucosal lesion segmentation in colonoscopy

Abstract: Accurate delineation of inflammatory lesions in colonoscopy is essential for the objective assessment of inflammatory bowel disease (IBD), yet remains challenging due to…

Date: 2026-07-22

SIRT1 rs2394445 associates with serum triacylglycerol lipidomic profile in metabolic dysfunction-associated steatotic liver disease

Abstract: This exploratory study aimed to identify the effects of SIRT1 polymorphisms on the serum lipidomic profile and pathological characteristics in metabolic…

Date: 2026-07-22

Biological and clinical stability after switching from intravenous to subcutaneous natalizumab in RRMS under standard and extended dosing

Abstract: Natalizumab (NTZ) is a high-efficacy therapy for relapsing-remitting multiple sclerosis (RRMS) that can be administered intravenously (IV) or subcutaneously (SC). While…

Date: 2026-07-22

Real-world experience with RESCUE BT2 tirofiban protocol versus standard care for select patients with acute ischemic stroke at a United States comprehensive stroke center: a single-center retrospective study

Abstract: Tirofiban, a glycoprotein IIb/IIIa receptor inhibitor, has shown promise in acute ischemic stroke (AIS) without medium- or large-vessel occlusion. The RESCUE BT2 trial…

Date: 2026-07-22

Beyond motor dysfunction: comorbidities in children with cerebral palsy: a retrospective observational study from a tertiary paediatric hospital in the UAE

Abstract: Cerebral palsy (CP) is associated with comorbidities affecting motor, cognitive, and sensory function, which may be present at various levels in different patients,…

Date: 2026-07-22

Implications of isonicotinylation-associated patterns in NK cells in the pathogenesis of Kawasaki disease: evidence from artificial intelligence-driven multi-omics and clinical validation

Abstract: Kawasaki disease (KD) is a systemic vasculitis of childhood driven by aberrant immune activation. Natural killer (NK) cell dysregulation plays a critical role, but its…

Date: 2026-07-22

IL-33 promotes efferocytosis by peritoneal macrophages by a mechanism associated with rapid granulocyte IL-13 production

Abstract: Resolution of inflammation is an active process that requires efferocytosis, the engulfment of apoptotic cells by macrophages, mediated by receptors such as MerTK. IL-33…

Date: 2026-07-22

Fermentable fiber supplementation in pigs promotes anti-parasitic defense mechanisms and impacts parasite growth in Ascaris suum infection

Abstract: Ascarids are among the most prevalent soil-transmitted helminths affecting both humans and livestock, particularly pigs. While reduced anthelmintic efficacy has been…

Date: 2026-07-22

Mortality risk stratification in antineutrophil cytoplasmic antibody-associated vasculitis: baseline severity, accumulated damage burden and cardio-renal vulnerability in a Chinese two-center cohort

Abstract: Mortality in antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is influenced by active inflammation, organ-threatening severity, irreversible damage and…

Date: 2026-07-22