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Insulin potentiates lipopolysaccharide-induced IL-6 expression through epigenetic remodeling in adipocytes: in vitro and in vivo mechanistic study

Abstract: Interleukin-6 (IL-6) is a central mediator of chronic low-grade inflammation associated with metabolic disease. Because obesity is characterized by elevated circulating…

Date: 2026-07-08

Increased phenotypic and functional stability of human allospecific induced Tregs is associated with Vitamin C-mediated FOXP3 TSDR demethylation

Abstract: While numerous preclinical models emphasize the therapeutic promise of in vitro -induced Tregs (iTregs) for managing inflammatory diseases and promoting tolerance, their…

Date: 2026-07-08

Integrated approach of guided honest disclosure and palliative care for advanced lung cancer: impacts on emotional distress, symptom burden, and patient satisfaction

Abstract: To explore the feasibility and clinical value of a comprehensive nursing model that integrates guided open communication strategies with the philosophy of palliative…

Date: 2026-07-08

Utilization of immunotherapy as a neoadjuvant treatment in liver transplant recipients with hepatobiliary carcinoma

Abstract: Hepatobiliary carcinoma (HBC) ranks as the sixth most prevalent cancer worldwide. Orthotopic liver transplantation (OLT) has emerged as a highly effective treatment…

Date: 2026-07-08

Unraveling the role of PPFIA1 in cancer: a comprehensive multi-omics analysis and functional validation from pan-cancer to pancreatic cancer

Abstract: PTPRF interacting protein alpha 1 (PPFIA1), a cytoplasmic scaffold protein of the liprin family, modulates cell adhesion, signal transduction, and cytoskeletal dynamics.…

Date: 2026-07-08

Prevalence of secondary traumatic stress and its associated factors among oncology nurses: a multicenter cross-sectional study

Abstract: Although secondary traumatic stress (STS) is common in nurses and is associated with various psychological disorders such as anxiety and depression, the prevalence and…

Date: 2026-07-08

MemSAM-2.5D: overcoming volumetric discontinuity and boundary ambiguity for 3D liver tumor segmentation

Abstract: Accurate segmentation of liver tumors from 3D computed tomography (CT) volumes is essential for the clinical management of hepatocellular carcinoma (HCC), but remains…

Date: 2026-07-08

Efficacy and safety of combining radiotherapy with first-line chemotherapy and immunotherapy for local advanced/metastatic urothelial cancer: a propensity score matching analysis

Abstract: This study evaluates the effectiveness and safety of combining radiotherapy with first-line chemotherapy and immune checkpoint inhibitors in patients with locally…

Date: 2026-07-08

Survival outcomes of axillary de-escalation following neoadjuvant chemo-immunotherapy in clinically node-positive triple-negative breast cancer: a national cancer database study

Abstract: Adding immune checkpoint inhibitors (ICIs) to neoadjuvant chemotherapy (NAC) enhances systemic efficacy in triple-negative breast cancer (TNBC). However, its impact on…

Date: 2026-07-08

Implementing exercise interventions in pediatric oncology: an expert consensus framework from the FORTEe project

Abstract: Exercise therapy is increasingly recognized as an integral component of supportive care in pediatric oncology. However, exercise programs are not yet widely implemented…

Date: 2026-07-08