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Crucial role of IL-6, IL-8, IL-11 and leptin in tumor microenvironment in a group of patients with GEP-NETs- crosstalk between inflammation and cancer

Abstract: GEP-NETs constitute a heterogeneous group of rare cancers arising in biologically diverse microenvironments, while their cytokine profiles remain insufficiently…

Date: 2026-07-02

Insulin resistance as a predictor of long-term adverse cardiovascular event risk in patients with atrial fibrillation following radiofrequency catheter ablation

Abstract: Catheter ablation is the first-line therapy for atrial fibrillation (AF), yet a significant proportion of patients experience major adverse cardiovascular events (MACEs)…

Date: 2026-07-02

Association of the combined triglyceride glucose-body mass index and serum IQGAP3 in appraising coronary lesion severity in type 2 diabetes

Abstract: IQGAP3 is a novel scaffold protein involved in inflammatory and metabolic regulation and may contribute to atherosclerosis. However, its clinical significance in…

Date: 2026-07-02

Freely accessible large language models for parent education in pediatric immune thrombocytopenia: an expert-rated cross-sectional study of safety, readability, and guideline concordance

Abstract: Parents of children with immune thrombocytopenia (ITP) increasingly turn to freely available large language models (LLMs) when they need quick explanations. In pediatric…

Date: 2026-07-01

Humoral responses to SARS-CoV-2 vaccination in allogeneic hematopoietic cell transplantation patients resemble that of healthy individuals

Abstract: Allogeneic hematopoietic cell transplantation (alloHCT) recipients are at increased risk of severe COVID-19. Although vaccination is strongly recommended, immune…

Date: 2026-07-01

Extracellular vesicles as prognostic biomarkers: results of a neoadjuvant chemoimmunotherapy clinical trial in stage IIIA (N2) non-small-cell lung cancer (SAKK 16/14)

Abstract: The introduction of immune checkpoint inhibitors has transformed cancer therapy. In non-small-cell lung cancer (NSCLC), immune-checkpoint blockade targeting programmed…

Date: 2026-07-01

Tirzepatide and reduced risk of pulmonary embolism and deep vein thrombosis: a multicenter U.S. cohort study

Abstract: Tirzepatide is a dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist used in patients with type 2 diabetes and obesity.…

Date: 2026-07-01

Pathogenic profiles and antimicrobial resistance in neutropenic acute leukemia patients: diagnostic potential of sTNF-R1 and IL-8

Abstract: To analyze the etiological characteristics, antimicrobial resistance patterns of infections during the neutropenic phase in acute leukemia (AL) patients, and to evaluate…

Date: 2026-07-01

Association of age, BMI and their interaction with thyroid nodules in patients with type 2 diabetes mellitus: a cross-sectional study

Abstract: Type 2 diabetes mellitus (T2DM) and thyroid nodules are both prevalent endocrine conditions; the prevalence of comorbidity between the two continues to rise. However,…

Date: 2026-07-01

Association between triglyceride-to-high-density lipoprotein cholesterol ratio and albuminuria in patients with type 2 diabetes: a cross-sectional study

Abstract: Previous studies have demonstrated that the triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio is closely related to chronic kidney disease and…

Date: 2026-07-01