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The association between estimated glucose disposal rate and self-reported diabetic retinopathy: evidence from two independent cohorts and machine learning

Abstract: Insulin resistance plays a key role in the pathogenesis of diabetic retinopathy (DR). Although established insulin resistance markers have been shown to predict a…

Date: 2026-06-26

Effects of age on the genetic and clinical characteristics of retinitis pigmentosa

Abstract: This study aimed to investigate how age affects the genetic and clinical characteristics of retinitis pigmentosa (RP), focusing on the detectability of causative genes…

Date: 2026-06-26

Comparison of efficacy and cost-effectiveness between mobile-bearing and fixed-bearing unicompartmental knee arthroplasty for elderly patients with knee osteoarthritis: a retrospective cohort study

Abstract: To compare the mid-term efficacy and cost-effectiveness of unicompartmental knee arthroplasty using a Mobile-Bearing and a Fixed-Bearing in elderly patients with knee…

Date: 2026-06-26

Comparative analysis of two modified TLICS systems in guiding surgical decision-making for thoracolumbar fractures

Abstract: To compare the Novel Modified Thoracolumbar Injury Classification System (NmTLICS) and the China-modified Thoracolumbar Injury Classification System (CN-mTLICS) in…

Date: 2026-06-26

Reliability and reproducibility of the modified thoracolumbar injury classification and severity score and the thoracolumbar AO spine injury score for guiding surgical decision-making in thoracolumbar fractures

Abstract: To evaluate the reliability and reproducibility of the modified Thoracolumbar Injury Classification and Severity Score (mTLICS) and the Thoracolumbar AO Spine Injury…

Date: 2026-06-26

An innovative 2D optical navigation workflow for percutaneous pedicle screw fixation in thoracolumbar fractures: comparison with O-arm 3D navigation

Abstract: Thoracolumbar fractures (TLFs) are common spinal injuries caused by high-energy trauma, falls, or osteoporosis. Traditional open surgery may involve substantial blood…

Date: 2026-06-26

Knowledge gaps, psychological burden, and patient-reported symptom severity and daily functioning in autoimmune gastritis: a observational survey of Chinese patients

Abstract: Autoimmune Gastritis (AIG) is a chronic inflammatory disorder characterized by autoimmune-mediated damage to the gastric mucosa, leading to gastric atrophy and may…

Date: 2026-06-26

Dietary diversity, migration experience, and brain volume in middle-aged and older adults in rural Japan: a cross-sectional magnetic resonance imaging study

Abstract: To identify lifestyle, social, and health-related factors associated with normalized brain volume (NBV), an imaging marker of brain atrophy, among community-dwelling…

Date: 2026-06-26

HMGB1-TLR4 signaling-mediated neuroinflammation contributes to the pathogenesis of infantile epileptic spasms syndrome in rats

Abstract: Infantile epileptic spasm syndrome (IESS) is a severe age-dependent epileptic encephalopathy in infancy with poor prognosis and unclear pathogenesis. Neuroinflammation…

Date: 2026-06-26

Patient and caregiver perspectives on transition from pediatric to adult care in inborn errors of immunity: a Polish multicenter survey

Abstract: Advances in the diagnosis and treatment of inborn errors of immunity (IEI) have improved survival rates, resulting in a growing population of adolescents requiring…

Date: 2026-06-26