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An exploratory integrative analysis of plasma transcriptomic and proteomic predictors of response to total neoadjuvant therapy in locally advanced rectal cancer

Abstract: LARC patients exhibit heterogeneity in their response to total neoadjuvant therapy (TNT). This study aims to screen and identify plasma biomarkers associated with…

Date: 2026-06-08

S-GRAS score and the complementary prognostic value of neutrophil-to-lymphocyte ratio in adrenocortical carcinoma: evidence for a synergistic interaction

Abstract: This study aimed to assess the prognostic values of the S-GRAS model and two of the most frequently used inflammation-based scores – neutrophil-to-lymphocyte ratio (NLR)…

Date: 2026-06-08

Cardiac arrhythmias following COVID-19 vaccination: insights from the U.S. vaccine adverse event reporting system (VAERS), December 2020—January 2025, United States

Abstract: Although COVID-19 vaccines are highly effective in preventing infection and severe disease, their cardiovascular safety, particularly regarding arrhythmic risk,…

Date: 2026-06-08

The influence of C-reactive protein-triglyceride-glucose index (CTI) on the prognosis of heart failure patients with different ejection fractions

Abstract: The C-reactive protein-triglyceride-glucose index (CTI) is a novel biomarker integrating inflammation and insulin resistance. Its prognostic value for all-cause…

Date: 2026-06-08

Leveraging dynamic serum uric acid trajectories for risk stratification in hospitalized HFpEF patients

Abstract: Single-timepoint SUA measurement provides limited prognostic insight in acute heart failure with preserved ejection fraction (HFpEF). This study assessed whether dynamic…

Date: 2026-06-08

Targeting WNK1 suppresses acute myeloid leukemia progression and enhances sensitivity to venetoclax

Abstract: The With-No-Lysine (WNK) kinase family plays critical roles in cellular signaling, yet its significance in acute myeloid leukemia (AML) remains unclear. We analyzed…

Date: 2026-06-05

Prevalence of undernutrition at admission and associated factors among children with cancer admitted to the University Hospital of Tangier: a cross-sectional study

Abstract: In pediatric oncology, undernutrition is a silent emergency. In developing countries, the situation is exacerbated by socio-economic insecurity and limited availability…

Date: 2026-06-05

Distinct systemic metabolic signatures in premenopausal women with lipedema revealed by composite indices

Abstract: Lipedema is a chronic adipose tissue disorder with disproportionate fat accumulation in the extremities and is often misdiagnosed as obesity. Although women with…

Date: 2026-06-05

Development and validation of a nomogram model for predicting cardiac autonomic neuropathy in patients with diabetes

Abstract: Diabetic Cardiac Autonomic Neuropathy (DCAN), a critical yet frequently underdiagnosed microvascular complication, is associated with increased mortality. Standard…

Date: 2026-06-05

Metformin attenuates diabetic osteoporosis via the miR-21 mediated Mef2c/Sost pathway

Abstract: ObjectiveThis study aimed to explore the role of the miR-21/Mef2c/Sost pathway in the pathogenesis of diabetic osteoporosis (DOP) and to investigate whether metformin…

Date: 2026-06-05