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Discrepancy between central nervous system involvement at diagnosis and relapse burden in childhood acute lymphoblastic leukemia: a five-year cohort study in a middle-income setting

Abstract: Central nervous system (CNS) involvement is a critical prognostic factor in childhood acute lymphoblastic leukemia (ALL). Conventional cytology remains the diagnostic…

Date: 2026-05-29

Serum sST2 and MR-ProADM in pediatric acute rheumatic fever: association with cardiac involvement and clinical risk stratification

Abstract: Acute rheumatic fever (ARF) remains a major cause of acquired heart disease in children, particularly in low- and middle-income countries. Cardiac involvement is the…

Date: 2026-05-29

Association of the neonatal sequential organ failure assessment score with neurological outcomes in infants diagnosed with hypoxic-ischemic encephalopathy

Abstract: Early identification of neurodevelopmental impairment (NDI) risk in neonates with hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) may…

Date: 2026-05-29

Clinical significance of serum brain-derived neurotrophic factor and serotonin levels in children with tic disorders

Abstract: Tic disorders (TD) are diagnosed mainly through clinical observation, and accessible peripheral biomarkers that reflect neurobiological alterations remain limited.…

Date: 2026-05-29

Pediatric pleural empyema - decision making beyond imaging - a retrospective cohort study

Abstract: In children and infants, thoracic empyema most often develops as a complication of parapneumonic pleural effusions progressing to purulent collections. With an estimated…

Date: 2026-05-29

Clinical Spectrum, independent risk factors, and treatment outcomes of pediatric arrhythmias: a multicenter retrospective analysis in Xinjiang

Abstract: Pediatric arrhythmias are heterogeneous and differ from adult disease in presentation and management; evidence from geographically vast, resource-variable regions of…

Date: 2026-05-29

Machine learning-based identification of an oxidative phosphorylation signature for prognosis, immune infiltration, and drug sensitivity in ovarian cancer

Abstract: Ovarian cancer (OC) is a highly heterogeneous disease, and its metabolic characteristics also exhibit heterogeneity. However, the specific metabolic pathways that play a…

Date: 2026-05-29

Disaster-related healthcare system disruption and maternal–neonatal outcomes

Abstract: Natural disasters disrupt healthcare systems and create crises that severely impact maternal and perinatal health outcomes. The 2023 Kahramanmara? earthquakes caused…

Date: 2026-05-29

HPV genotype-specific p16/Ki67 expression with machine learning-assisted assessment in cervical neoplasia

Abstract: Genotype-specific patterns of dual p16/Ki67 immunoexpression and their integration with computational assessment remain insufficiently delineated in cervical neoplasia.…

Date: 2026-05-29

Study on the predictive value of NHR and UHR levels in early pregnancy for gestational diabetes mellitus: based on a retrospective analysis

Abstract: This study aims to examine the relationship between the neutrophil to high-density lipoprotein cholesterol ratio (NHR) and the uric acid to high-density lipoprotein…

Date: 2026-05-29