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Cardiac and aerobic response to growth hormone therapy in children with short stature: a prospective study using VO 2 max and speckle tracking echocardiography

Abstract: Recombinant human growth hormone (r-hGH) enhances somatic growth and body composition, yet its short-term effects on aerobic capacity and myocardial function remain…

Date: 2026-05-28

Familial glucocorticoid deficiency due to a novel TXNRD2 variant: expanding the spectrum of a rare genetic cause

Abstract: Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder characterized by isolated cortisol deficiency and elevated adrenocorticotropic hormone…

Date: 2026-05-28

Isoflurane for difficult sedation in critically ill children: a retrospective analysis in a mixed pediatric intensive care population

Abstract: When standard intravenous regimens fail, children in the pediatric intensive care unit often face escalating sedative polypharmacy with potential harm; we therefore…

Date: 2026-05-28

An evaluation of factors associated with hypertension in children and adolescents with obesity

Abstract: Childhood hypertension and obesity are among the most prevalent health conditions worldwide, with obesity increasing the risk of hypertension in children. However, there…

Date: 2026-05-28

TP53 deficiency induces a low-adhesion transcriptomic signature correlating with accelerated CAR-T cell exhaustion in B-ALL

Abstract: Chimeric antigen receptor T-cell (CAR-T) therapy is a potent treatment for relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL). However, patients…

Date: 2026-05-28

Insights into epidemiological and clinical burden of bronchiolitis among hospitalized children: a call for preventive interventions

Abstract: Bronchiolitis is a leading cause of hospitalization in infants under 2 years, with seasonal surges that strain healthcare systems. Despite its prevalence, management…

Date: 2026-05-28

Predictive performance of the PSU-neonatal early warning score in identifying newborns requiring intensive care

Abstract: The Prince of Songkla University (PSU)-neonatal early warning score (PSU-NEWS) was developed to assist nurses in rapidly assessing the neonatal status and communicating…

Date: 2026-05-28

Muscle fitness and physical function in children and adolescents with newly diagnosed cancer

Abstract: Maintaining muscle health is crucial for children undergoing cancer treatment. However, the extent of impairments during the early stages of treatment remains sparsely…

Date: 2026-05-28

Impact of red blood cell transfusion and transfusion strategies on clinical outcomes in extremely low gestational age neonates

Abstract: To investigate the effects of red blood cell transfusions and transfusion strategies on clinical outcomes in extremely low gestational age neonates (ELGANs). This…

Date: 2026-05-28

A disulfide-bridged single-stranded DNA nanotube for co-delivery of siRNA and chemotherapeutics in ovarian cancer therapy

Abstract: Using DNA nanotechnology, we designed a disulfide-bridged single-stranded DNA nanotube (SS-DNT) functionalized with external aptamers for targeting, and encapsulating…

Date: 2026-05-28