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Conditional myeloid-specific deletion of Ube2n hinders YUMM1.7 melanoma growth

Abstract: The role of UBE2N in myeloid cell-mediated immune suppression in cancer remains undefined. Here, we examined the function of UBE2N in myeloid cell-mediated tumor…

Date: 2026-09-24

Periodic fever, aphthous stomatitis, pharyngitis, adenitis: clinical manifestations, response to steroids, and a practice of online diagnosis and follow-up

Abstract: Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome, although not rare, is frequently underdiagnosed. This might be related to the fact that…

Date: 2026-09-24

Earlier bedtime at 1.5?years is associated with greater height gain at 3?years of age: a nationwide birth cohort study of the Japan environment and children’s study

Abstract: Previous studies have shown inconsistent associations between sleep duration and height gain in early childhood. The relationships of bedtime and nighttime awakenings…

Date: 2026-09-24

Comparative effectiveness and safety of topiramate versus amitriptyline for the prophylactic management of chronic migraine: a prospective comparative study

Abstract: Chronic migraine is a chronic disabling neurological disease and has a significant impact on quality of life. Topiramate and amitriptyline are commonly used for migraine…

Date: 2026-09-24

Educational environment perceptions across curriculum formats: structural associations among DREEM domains and academic self-perceptions

Abstract: Team-Based Learning (TBL) is increasingly used in health professions education; however, the Dundee Ready Education Environment Measure (DREEM) has rarely been formally…

Date: 2026-09-24

Association of the systemic immune-inflammation index with consciousness disturbance in cerebral venous sinus thrombosis: a retrospective cohort study

Abstract: Consciousness disturbance (CD) is a severe neurological manifestation of cerebral venous sinus thrombosis (CVST), but the association between the systemic…

Date: 2026-09-24

Exploring the impact of Chinese medicine on CD4 cell counts in people living with HIV by mixed-effects model: a retrospective cohort study based on propensity score matching

Abstract: CD4 cells are the targets of human immunodeficiency virus (HIV). If left untreated, HIV enters CD4 cells and replicates, ultimately leading to the death of the infected…

Date: 2026-09-24

Development and comparative evaluation of machine learning algorithms and Cox regression for predicting fasting plasma glucose-defined incident prediabetes: a longitudinal cohort study

Abstract: To develop, compare, and externally evaluate machine learning (ML) and Cox regression models for predicting fasting plasma glucose (FPG)-defined incident prediabetes. We…

Date: 2026-09-24

Comparative analysis of cataract surgery outcomes in elderly Jewish and Arab patients from Northern Israel, a retrospective cohort study

Abstract: To compare postoperative visual recovery and complications after cataract surgery between Jewish and Arab elderly patients in Northern Israel within a shared healthcare…

Date: 2026-09-24

Development and internal–external validation of an interpretable machine learning model integrating clinical and polygenic predictors for coronary artery disease: a multicenter retrospective cohort study

Abstract: Accurate primary-prevention risk stratification for coronary artery disease (CAD) remains challenging. We developed and internally validated a framework integrating…

Date: 2026-09-24