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An interpretable prediction model for non-invasive identification of the phlegm-dampness constitution based on machine learning

Abstract: In traditional Chinese medicine (TCM), constitutional types influence disease susceptibility. Phlegm-Dampness Constitution (PDC), a common subtype, has been linked to…

Date: 2026-09-22

Development and validation of a machine learning-based diagnostic model for obstructive coronary artery disease in hypertensive patients using composite inflammatory and lipid markers

Abstract: Hypertensive patients face high risk of obstructive coronary artery disease (CAD), but early diagnosis is limited by costly or invasive gold-standard imaging. Composite…

Date: 2026-09-22

Immunohistochemical profiling of PD-L1 expression in neuroendocrine carcinoma of the uterine cervix

Abstract: Neuroendocrine carcinoma (NEC) of the uterine cervix is a rare and aggressive malignancy for which disease-specific treatment strategies remain limited. Although immune…

Date: 2026-09-22

Association between sleep and ovarian reserve in women undergoing IVF/ICSI: a Mendelian randomization and cross-sectional study

Abstract: Sleep and circadian rhythm disruptions are recognized risk factors for impaired fertility, but their effects on ovarian reserve and underlying mechanisms remain unclear.…

Date: 2026-09-22

Melatonin is associated with cell-type-specific inflammatory and oxidative stress responses at the maternal-fetal interface

Abstract: Melatonin regulates inflammation and oxidative stress at the placenta, but its effects on specific placental cell types remain unclear. This study investigated how…

Date: 2026-09-22

Association of mild cognitive impairment and comorbid depression with postoperative delirium in patients undergoing knee/hip arthroplasty: a prospective cohort study

Abstract: Postoperative delirium (POD) is common after surgery, involving acute disturbances in attention and cognition. While mild cognitive impairment (MCI) and depression each…

Date: 2026-09-22

Suicide probability among physicians: an explainable machine learning analysis of depression, burnout, anxiety, and coping styles

Abstract: Suicide is a major public health concern, and physicians are at increased risk because of demanding working conditions and a high prevalence of mental health problems.…

Date: 2026-09-22

Timing of depressive episode onset relative to chronic pain reveals distinct patterns of affective and multisite pain

Abstract: Prior research shows the relationship between chronic pain and depression is bidirectional, with co-occurrence associated with worse functional outcomes. However, few…

Date: 2026-09-22

Impact of surgical complexity and surgeon experience on phacoemulsification outcomes: a one-year retrospective study from a Saudi tertiary eye hospital

Abstract: This study aimed to assess one-year outcomes of phacoemulsification cataract surgery at King Khaled Eye Specialist Hospital (KKESH), a tertiary referral teaching…

Date: 2026-09-22

A method for distinguishing and separating retinal microglia from infiltrating macrophages during an ocular inflammatory event

Abstract: A significant challenge in the study of neuroimmune responses is the identification and separation of resident microglia from infiltrating bone marrow-derived…

Date: 2026-09-22