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Metaplastic breast carcinoma versus triple-negative breast cancer: distinct metastatic patterns and inferior overall survival in a matched retrospective cohort study

Abstract: Metaplastic breast carcinoma (MBC) is an uncommon invasive breast cancer subtype with marked morphological diversity. Many MBCs are managed within the triple-negative…

Date: 2026-09-22

A palmitoylation-related signature predicts prognosis and immune microenvironment features in diffuse large B-cell lymphoma

Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive lymphoma and remains highly heterogeneous in prognosis. Palmitoylation, an important…

Date: 2026-09-22

Baseline indices of cardiorespiratory fitness for predicting acute mountain sickness: an interpretable four-task ensemble model

Abstract: Acute mountain sickness (AMS) poses formidable challenges for individuals venturing into high-altitude (HA) environments. Early and precise prediction of AMS is crucial…

Date: 2026-09-22

Barriers to social participation among patients with hemophilia: a qualitative study using social-ecological systems theory

Abstract: Social participation greatly determines health-related quality of life, while people with hemophilia face severe social engagement restrictions. Current studies only…

Date: 2026-09-21

Single-cell virtual knockout network perturbation prioritizes candidate regulators of beta-cell functional failure in type 2 diabetes

Abstract: Progressive pancreatic beta-cell dysfunction is a central feature of type 2 diabetes (T2D), but disease-associated transcriptional changes alone cannot distinguish…

Date: 2026-09-21

The nomogram prediction model for primary aldosteronism: the combination of serum and urine electrolytes and serum uric acid

Abstract: To construct and preliminarily validate a novel nomogram for primary aldosteronism (PA) risk estimation, with the goal of providing a potential reference tool for PA…

Date: 2026-09-21

Lp(a), platelet count, aspirin and cardiovascular outcome: a prospective cohort analysis

Abstract: Elevated lipoprotein(a) [Lp(a)] and increased platelet count independently predict major adverse cardiovascular events (MACE), yet their interplay and joint value in…

Date: 2026-09-21

Weight-adjusted waist index and its association with diabetic peripheral neuropathy in patients with type 2 diabetes: a cross-sectional study in coastal Zhejiang province

Abstract: To investigate the association between the weight-adjusted waist index (WWI) and the risk of diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes…

Date: 2026-09-21

Prediction models for refractory Mycoplasma pneumoniae pneumonia and corticosteroid treatment escalation in hospitalized children: a retrospective cohort study

Abstract: Mycoplasma pneumoniae carries a clinically important risk of a refractory course or the need for intensified corticosteroid therapy. No admission-day prediction tool has…

Date: 2026-09-21

Clinical usefulness of objective tongue image devices monitoring in temporal tongue color: a demonstration of successively treated cases with traditional medicines

Abstract: In Kampo medicine (traditional Japanese medicine), the diagnostic method of observing a patient's tongue is called the ‘tongue diagnosis’. Information provided by…

Date: 2026-09-21