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FDG-PET/MR in paediatric pyrexia of unknown origin: early detection of Takayasu arteritis—a single-centre experience

Abstract: Pyrexia of unknown origin (PUO) in children presents a significant diagnostic challenge owing to its broad and heterogeneous aetiology. Among autoimmune causes,…

Date: 2026-09-21

Psychosomatic symptom profiles and associated factors of clinically significant anxiety symptoms among breast cancer patients receiving chemotherapy: a multicenter cross-sectional study in China

Abstract: Chemotherapy is a cornerstone of breast cancer treatment, but chemotherapy-induced adverse events and psychosocial factors often impair patients’ quality of life and…

Date: 2026-09-21

Subclinical pulmonary embolism in first-line/induction therapy of lung cancer - a remaining clinically relevant adverse event

Abstract: Pulmonary embolism (PE) at initial diagnosis and during first-line systemic treatment is clinically relevant in patients with lung cancer. However, real-world incidence…

Date: 2026-09-21

Development and external validation of an interpretable deep learning model for early immune-related adverse events in hepatocellular carcinoma

Abstract: To develop and externally validate an interpretable deep learning model for pre-treatment prediction of early clinically significant immune-related adverse events in…

Date: 2026-09-21

Malnutrition as an independent risk factor for fluoropyrimidine- and oxaliplatin-based chemotherapy-induced cardiovascular toxicity in colorectal cancer: a single-center retrospective cohort study

Abstract: Fluoropyrimidine- and oxaliplatin-based regimens (FOLFOX/XELOX) are the standard of care for colorectal cancer (CRC) but carry significant cardiovascular toxicity.…

Date: 2026-09-21

TGF-?-induced epithelial to mesenchymal transition drives proteoglycan binding specificity of HPV-based drug conjugates for cancer cells

Abstract: Human papillomaviruses (HPVs) utilize specifically modified proteoglycans (PGs) within the basement membrane as attachment factors prior to cell entry and infection.…

Date: 2026-09-21

Myeloid EGR1 contributes to Th17/Treg imbalance during acute liver allograft rejection in a rat model

Abstract: Ischemia-reperfusion injury (IRI) and acute rejection (AR) limit liver transplantation success. Early growth response 1 (EGR1) mediates stress and inflammation, yet its…

Date: 2026-09-21

ARID1A deficiency identifies molecular alterations and potential therapeutic implications in cervical clear cell carcinoma: an integrated genomic and clinicopathological study

Abstract: Cervical clear cell carcinoma (CCC) is a rare and aggressive subtype of cervical adenocarcinoma whose molecular drivers and therapeutic vulnerabilities remain…

Date: 2026-09-21

EV-derived miR-1246 promotes lymph node metastasis in esophageal squamous cell carcinoma through targeting the PPP2CB/NF-?B axis

Abstract: Lymph node metastasis (LNM) is a critical factor contributing to poor prognosis in esophageal squamous cell carcinoma (ESCC) patients. Consequently, elucidating its…

Date: 2026-09-21

Association of metabolic indices with in-stent restenosis and its angiographic severity after drug-eluting stent implantation: a case-control study

Abstract: Metabolic abnormalities may contribute to in-stent restenosis (ISR) after percutaneous coronary intervention, but the comparative associations of commonly used metabolic…

Date: 2026-09-21