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GSTP1 as a senescence-associated diagnostic candidate in prostate cancer: integrative bioinformatics and functional validation

Abstract: Prostate cancer (PCa) is a common malignancy of the male genitourinary system with high metastatic potential and poor clinical outcomes, for which effective biomarkers…

Date: 2026-10-08

Integrated hs-cTnI, global longitudinal strain, and coronary artery calcium for risk stratification of anthracycline-related cardiac dysfunction in multiple myeloma

Abstract: Anthracycline-related cardiac dysfunction remains a major concern in multiple myeloma, yet conventional left ventricular ejection fraction (LVEF) surveillance may miss…

Date: 2026-10-08

Long-term survival after transcatheter aortic valve implantation in nonagenarian patients: a multicenter real-world study

Abstract: The growing number of nonagenarian patients with severe aortic stenosis has increased interest in transcatheter aortic valve implantation (TAVI) in this population.…

Date: 2026-10-08

A screening method for aortic valve disease based on spectral analysis of a single-channel electrocardiogram using machine learning algorithms

Abstract: Given the high prevalence of aortic heart disease and the importance of early diagnosis, there is a need to develop a simple screening method to identify significant…

Date: 2026-10-08

Association of NT-proBNP/LVEF with angiographic coronary disease burden in acute myocardial infarction: a retrospective study with machine learning analyses

Abstract: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and left ventricular ejection fraction (LVEF) reflect complementary dimensions of ventricular stress and systolic…

Date: 2026-10-08

A predictive model for cytarabine syndrome-associated febrile episodes in children with acute lymphoblastic leukemia

Abstract: This study aims to develop a predictive model for cytarabine syndrome (CS)-related fever in pediatric patients with acute lymphoblastic leukemia (ALL). By integrating…

Date: 2026-10-07

Dynamic fibrinogen decline rate outperforms static admission values in predicting hematoma expansion in APL-related intracranial hemorrhage: a retrospective cohort study

Abstract: Intracranial hemorrhage (ICH) is the leading cause of early death in acute promyelocytic leukemia (APL). Current risk assessment relies on static coagulation parameters…

Date: 2026-10-07

Overall survival after relapse in high-risk neuroblastoma: an adjusted indirect comparison of post-relapse dinutuximab beta, historical controls, and relapse after first-line dinutuximab beta maintenance

Abstract: To compare overall survival (OS) in patients with relapsed neuroblastoma treated with dinutuximab beta (DB) after relapse with that of two comparator populations:…

Date: 2026-10-07

Capsaicin ameliorates diabetic nephropathy by targeted activation of GPX4 and inhibition of pyroptosis

Abstract: Capsaicin (CAP) is the primary pungent alkaloid found in chili peppers. The aim of this study is to screen for candidate therapeutic agents targeting the mitochondrial…

Date: 2026-10-07

Diabetic sarcopenia in clinical practice: expert consensus and usability evaluation of a novel screening and diagnostic algorithm

Abstract: Recently, an expert panel developed an algorithm for the screening, diagnosis, and staging of diabetic sarcopenia, a clinically relevant condition in the progression of…

Date: 2026-10-07