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Risk factors for advance stage cardiovascular-renal-metabolic syndrome in patients with early-onset type 2 diabetes mellitus

Abstract: To investigate the incidence of advanced cardiovascular-kidney-metabolic (CKM) syndrome and its associated risk factors in patients with early-onset type 2 diabetes…

Date: 2025-08-27

Investigating serum iodine nutritional levels and their correlation with thyroid function in adult patients with Graves’ hyperthyroidism at different treatment stages

Abstract: Investigate the thyroid function and thyroid autoantibodies in adult Graves’ disease (GD) patients at different treatment stages and healthy adults with serum iodine…

Date: 2025-08-27

Targeting IL-6 receptor mediated metabolic pathways to control Th17 cell differentiation and inflammatory responses

Abstract: Interleukin-6 (IL-6) is a multifunctional cytokine that plays important roles in inflammation. Several studies have shown that IL-6 regulates various aspects of T cell…

Date: 2025-08-27

Association of neonatal hypothermia with neonatal hypoglycemia

Abstract: About 15% of neonates suffer from hypoglycemia. Hypothermia is associated with hypoglycemia; however, there are limited empiric data analyzing this association.…

Date: 2025-08-27

Exploration of the active components and mechanisms of Epimedium for the treatment of Undescended Testis

Abstract: Undescended Testis, the most common congenital male reproductive disorder in children, demonstrates complex pathogenesis with genetic predisposition. While early…

Date: 2025-08-27

Development and validation of a prognostic nomogram for unresectable pancreatic ductal adenocarcinoma with synchronous liver metastases: a study based on the SEER database and an external cohort

Abstract: Pancreatic ductal adenocarcinoma with synchronous liver metastases (PDACLM) represents a highly aggressive malignancy with limited treatment options and poor prognosis.…

Date: 2025-08-27

Hydrogen sulfide as a therapeutic agent for diabetic wounds: effects on inflammation and fibroblast pyroptosis

Abstract: Chronic nonhealing wounds are one of the most serious complications of diabetes mellitus (DM), with limited treatment options. Hydrogen sulfide (H 2 S) plays a…

Date: 2025-08-27

Harnessing technology to enhance oral health literacy among Afghan women: an interprofessional community-engaged initiative

Abstract: Ongoing socio-political instability has resulted in a growing influx of Afghan women with limited literacy skills resettling in the United States (U.S.). These women…

Date: 2025-08-27

A genetically determined molecular switch modulates the anti-inflammatory potential of human IgA

Abstract: Fc receptor-driven immune system activity typically reflects a balance of activating and inhibitory mechanisms, mediated by the immunoreceptor tyrosine-based activation…

Date: 2025-08-27

Functional characterization and clinical significance of IGSF8 in pan-cancer: an integrated bioinformatic and experimental study

Abstract: Immunoglobulin superfamily member 8 (IGSF8) is a membrane protein implicated in crucial biological processes like cell interactions and immune responses. Emerging…

Date: 2025-08-27