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Standardizing CRISPR-Cas13 knockdown technique to investigate the role of cdh2 gene in pituitary development through growth hormone expression and transcription factors

Abstract: Introduction: Congenital hypopituitarism (CH) is characterized by the deficiency of pituitary hormones. Among CH patients, 85% lack a molecular diagnosis. Whole Exome…

Date: 2024-10-10

The expression of VDACs and Bcl2 family genes in pituitary adenomas: clinical correlations and postsurgical outcomes

Abstract: Introduction: Pituitary adenomas (PAs) are benign tumors with high prevalence and, occasionally, aggressive course. The tumorigenesis of these lesions is not completely…

Date: 2024-10-10

Efficacy of echolaser smart interface-guided laser ablation in volume reduction of symptomatic benign thyroid nodules

Abstract: Background: The management of benign symptomatic thyroid nodules until recent years has been limited to surgery, radioactive iodine treatment, or surveillance which is…

Date: 2024-10-09

Evaluating the feasibility and predictive accuracy of biodynamic imaging to platinum-based chemotherapy response in esophageal adenocarcinoma

Abstract: Background: Esophageal cancer management lacks reliable response predictors to chemotherapy. In this study we evaluated the feasibility and accuracy of Biodynamic…

Date: 2024-09-30

TAS-102 (trifluridine/tipiracil) plus bevacizumab versus TAS-102 alone as salvage treatment options for metastatic colorectal cancer in routine clinical practice

Abstract: Introduction: Both regimens of TAS-102 (trifluridine/tipiracil) with and without bevacizumab are considered standard options for salvage treatment in patients with…

Date: 2024-09-30

Care manager role for older multimorbid heart failure patients’ needs in relation to psychological distress and quality of life: a cross-sectional study

Abstract: Background: There are few studies investigating patients’ needs in healthcare focusing on disease severity and psychological characteristics of elderly heart failure…

Date: 2024-09-30

Cardiovascular magnetic resonance insights into anomalies of the mitral valve apparatus in Fabry cardiomyopathy and hypertrophic cardiomyopathy

Abstract: Background and aims: Despite different etiopathogenesis, Fabry Disease cardiomyopathy (FDc) and sarcomeric hypertrophic cardiomyopathy (HCM) share a similar hypertrophic…

Date: 2024-09-30

Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study

Abstract: Background: Gouty arthritis is a common inflammatory arthritis. The recurrent gout attacks severely damage the joint’s function, lead to bone erosion, and affect bone…

Date: 2024-09-30

Changes in serum uteroglobin level in type 2 diabetes mellitus patients

Abstract: Background: Uteroglobin is a multifunctional protein with anti-inflammatory properties. Studies have revealed the importance of inflammation in type 2 diabetes mellitus…

Date: 2024-09-30