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Longitudinal evaluation of T-cell responses to Pfizer-BioNTech and Janssen SARS-CoV-2 vaccines as boosters in Ghanaian adults

Abstract: In Ghana, at least five different COVID-19 vaccines based on mRNA or adenovirus vector delivery platforms have been authorized by the Ghana Health Service for…

Date: 2025-09-12

The immunomodulatory and antitumor properties of the bacterial metalloprotease Oligopeptidase A are mediated by TLR4/MyD88/TRIF and MAPK signaling pathways

Abstract: Immunosuppressive factors within the tumor microenvironment hinder effective antitumor immune responses and limit the efficacy of current immunotherapies.…

Date: 2025-09-12

Association of dietary fiber intake with all-cause and cardiovascular mortality in U.S. adults with metabolic syndrome: NHANES 1999–2018

Abstract: Low dietary fiber intake is common in the US, despite its health benefits. Individuals with metabolic syndrome (MetS), at high cardiovascular risk, may benefit…

Date: 2025-09-11

Safety assessment of gemtuzumab ozogamicin: real-world adverse event analysis based on the FDA Adverse Event Reporting System

Abstract: To mine adverse drug events (ADEs) following the use of gemtuzumab ozogamicin based on the FDA Adverse Event Reporting System (FAERS), and to provide references for the…

Date: 2025-09-11

Distinct effects of semaglutide and tirzepatide on metabolic and inflammatory gene expression in brown adipose tissue of mice fed a high-fat, high-fructose diet

Abstract: Brown adipose tissue (BAT) is crucial for overall energy homeostasis as a thermogenic organ with high metabolic activity. While the recruitment of BAT contributes to…

Date: 2025-09-11

Comparison of children with bioinactive growth hormone, small for gestational age, and idiopathic short stature

Abstract: Short stature has many causes, including rare disorders of GH function. Bioinactive growth hormone (GH) refers to a phenotype characterized by immunoreactive but…

Date: 2025-09-11

Endocrine complications after solid organ transplantation in childhood and adolescents

Abstract: Acute or chronic metabolic derangement following solid organ transplantation (SOT) often leads to endocrine complications, which have become more common as survival…

Date: 2025-09-11

Diagnostic and prognostic utility of salivary and serum procalcitonin, interleukin-6, and interleukin-10 in pediatric pneumonia: a prospective case-control study

Abstract: Effective biomarkers are essential for improving the diagnosis and risk stratification of pediatric pneumonia. This study aimed to evaluate the diagnostic and prognostic…

Date: 2025-09-11

Immunomodulatory factors CRP/albumin ratio and NLR predict post-spinal surgery infection

Abstract: The objective of this work is to investigate the predictive value of the neutrophil-to-lymphocyte ratio (NLR) combined with the C-reactive protein/albumin (CRP/ALB)…

Date: 2025-09-11

The risk prediction model for acute urine retention after perineal prostate biopsy based on the LASSO approach and Boruta feature selection

Abstract: One known side effect of transperineal (TP) prostate biopsies is acute urine retention (AUR). We aimed to create and evaluate a predictive model for the…

Date: 2025-09-11