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Continuation of atezolizumab plus bevacizumab beyond initial progressive disease: clinical benefits in patients with unresectable hepatocellular carcinoma – a multicenter cohort study

Abstract: The clinical significance of treatment beyond progression (TBP) with immune checkpoint inhibitor-based therapy in hepatocellular carcinoma (HCC) remains unclear. As…

Date: 2025-09-11

Capturing metabolic syndrome in low-resource settings: a case study in urban Haiti

Abstract: Local epidemiologic data on risk factors for heart disease are needed in low-income settings to guide targeted interventions for prevention and treatment. Metabolic…

Date: 2025-09-11

Elevating MHC I expression on tumor cells by nanovesicles loading tyrosine kinase inhibitors can improve the efficacy of cancer vaccines

Abstract: Cancer vaccines work through activating tumor-specific T cells, which can specifically attack cancer cells by recognizing antigens binding with…

Date: 2025-09-11

Efficiency divergence and convergence in China’s hospital sector: empirical insights from Guangdong Province using a multi-method approach

Abstract: Since the launch of China’s new round of healthcare system reforms in 2009, improving service efficiency has become a critical focus for enhancing the equitable…

Date: 2025-09-11

Development and validation of a predictive model for depression risk in patients with amyotrophic lateral sclerosis

Abstract: Depression is a severe neuropsychiatric manifestation in patients with amyotrophic lateral sclerosis (ALS), substantially impacting their quality of life and…

Date: 2025-09-11

UPLC/Q-TOF MS-based femoral muscle metabolomic analysis under high-temperature: a proof of concept for postmortem interval estimation

Abstract: Accurate postmortem interval (PMI) estimation is a major challenge in forensic medicine, especially for the rapidly and highly putrefied bodies in tropical…

Date: 2025-09-11

Geographic mapping and spatiotemporal patterns of tuberculosis in Libya within ten years' period (2015 to 2024)

Abstract: Tuberculosis(TB) is still a serious problem with a remarkable global impacts particularly within developing countries such as Libya. According to World Health…

Date: 2025-09-11

Evaluation of an intervention to improve waterless surgical hand antisepsis accuracy in a tertiary hospital of East China: a prospective pre-post intervention study

Abstract: Surgical site infections (SSIs) are the most frequent type of healthcare-associated infections (HAIs) in low- and middle-income countries (LMICs). Effective surgical…

Date: 2025-09-11

Construction and validation of a perioperative blood transfusion model for patients undergoing total hip arthroplasty with osteonecrosis of the femoral head based on machine learning

Abstract: This study aimed to construct a predictive model utilizing multiple machine learning (ML) models to estimate the likelihood of perioperative blood transfusion in…

Date: 2025-09-11

Impact of Fusobacterium nucleatum on immune cell interactions and gene expression in colorectal cancer: a retrospective cohort study

Abstract: Colorectal cancer (CRC) is a major global health concern. The presence of Fusobacterium nucleatum (Fn) in CRC can promote cancer progression by modulating the immune…

Date: 2025-09-11