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Securinine, a novel alkaloid, regulates cell cycle and EMT in gastric cancer by inducing iron-dependent cell death

Abstract: Gastric cancer remains one of the most prevalent and lethal cancers worldwide, with its insidious onset hindering early diagnosis and effective treatment. Despite…

Date: 2025-09-10

Archimedes navigation system-guided bronchoscopic trans-parenchymal nodule access for peripheral lung nodules: a single-center experience

Abstract: Peripheral pulmonary lesions (PPLs) present diagnostic challenges because of their small size and distal airway location, often requiring invasive surgical biopsies. The…

Date: 2025-09-10

Session-RPE for quantifying workload in olympic curling athletes

Abstract: To investigate the correlation between different workload methods among Olympic curling athletes. Eight curlers were monitored after training during Olympic seasons with…

Date: 2025-09-10

Detailed evaluation of sleep apnea using heart rate variability: a machine learning and statistical method using ECG data

Abstract: Sleep apnea is a common sleep disorder associated with high degree of autonomic dysfunction and increased cardiovascular risk. Traditional diagnostic methods such as…

Date: 2025-09-10

The relationship between albumin-corrected anion gap and hyperuricemia and its role in cardiovascular risk assessment: mediation effect analysis of triglycerides and non-high-density lipoproteins

Abstract: This study examines the relationship between Albumin-Corrected Anion Gap (ACAG) and hyperuricemia (HUA), as well as its potential mechanisms linking HUA to…

Date: 2025-09-10

Development and validation of a risk prediction model for distant metastasis in muscle-invasive bladder cancer: a retrospective study integrating SEER data with external validation cohort and biomarker analysis

Abstract: Bladder cancer (BCa) ranks among the most prevalent cancers in men, with a subset of patients developing distant metastases (DM), resulting in poor prognosis. This study…

Date: 2025-09-10

Navigating uncertainty in patient care: a closer look at emergency medicine residents in Brazil

Abstract: In emergency care, inexperience and case complexity can generate uncertainty and stress among physicians, impairing decision-making and impacting patients and the…

Date: 2025-09-10

Development and external validation of a nomogram for choosing postoperative adjuvant therapies in uterine sarcoma patients using real-world data

Abstract: This study aimed to develop and validate a prognostic nomogram to identify uterine sarcoma (US) patients who may not require adjuvant therapy after surgery, based on…

Date: 2025-09-10

Anxiety, depression, and fear after coronavirus disease 2019 infection and their association with long coronavirus disease symptoms

Abstract: The coronavirus disease 2019 (COVID-19) pandemic has had widespread physical and psychological repercussions. Additionally, long COVID symptoms such as fatigue, dyspnea,…

Date: 2025-09-10

Outcomes and predictors of mortality in patients with blunt chest trauma admitted to the intensive care unit: a retrospective study

Abstract: Blunt chest trauma (BCT) accounts for 25% of trauma-related deaths. we aimed to explore the outcomes and predictors of mortality in patients with BCT admitted to a…

Date: 2025-09-10