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The association between bone turnover biomarkers and the severity of white matter hyperintensities

Abstract: Bone health may be associated with cerebral small vessel disease. This study aims to explore the correlation between bone turnover biomarkers (BTMs) and parathyroid…

Date: 2025-09-19

Thrombus migration in intracranial large vessel occlusion: course, predictors, and impact on endovascular thrombectomy

Abstract: Thrombus migration (TM) is occasionally observed in patients with acute ischemic stroke undergoing endovascular thrombectomy (EVT) for large vessel occlusion. However,…

Date: 2025-09-19

Heterologous prime-pull mucosal vaccination with an adjuvanted RBD vaccine elicits robust IgA production and protects against SARS-CoV-2

Abstract: Despite the efficacy of approved severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in preventing severe disease and death, breakthrough infections…

Date: 2025-09-19

Opto-CD28-REACT: optogenetic co-stimulatory receptor activation on non-engineered human T cells

Abstract: T-cell activation is a highly regulated process requiring both antigen recognition via the T-cell receptor (TCR) and co-stimulatory signaling, notably through the…

Date: 2025-09-19

Blinatumomab demonstrates MRD eradication in MRD-positive/chemotherapy-delayed pediatric B-ALL and high response in relapsed/refractory cases: a multicenter cohort study

Abstract: Blinatumomab, a bispecific T-cell engager targeting CD3+ and CD19+, promotes T cell–mediated cytotoxicity against B-cell precursor acute lymphoblastic leukemia (B-ALL).…

Date: 2025-09-18

Single-cell profiling uncovers PTPRG-driven stemness in malignant plasma cells and signatures of treatment failure in multiple myeloma

Abstract: Multiple myeloma (MM) is characterized by extensive intratumoral heterogeneity and complex interactions within the bone marrow microenvironment, yet the cellular and…

Date: 2025-09-18

Association between triglyceride-glucose index and sarcopenia in patients with chronic kidney disease

Abstract: This study aimed to examine the relationship between the triglyceride-glucose index (TyG) and sarcopenia in patients with chronic kidney disease (CKD). The aim was to…

Date: 2025-09-18

Trends in commercial complementary food in Romanian infants–a cross-sectional study

Abstract: Good feeding practices beginning early in life and are crucial for preventing all forms of malnutrition and non-communicable diseases. This time frame encompasses the…

Date: 2025-09-18

Epidemiology and clinical aspect of pediatric mushroom poisonings: a 15-year retrospective analysis

Abstract: Mushroom poisoning is a significant public health concern, particularly in pediatric populations, where developmental differences in toxin metabolism and organ…

Date: 2025-09-18

Follicular fluid-derived small extracellular vesicles during individual in vitro maturation improve blastocyst development

Abstract: We evaluated the impact of follicular fluid-derived small extracellular vesicles (FF-sEVs) supplementation during oocyte maturation in vitro on bovine embryo outcomes,…

Date: 2025-09-18