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Adolescent substance use in Costa Rica: findings from a national survey among secondary school students

Abstract: Adolescent substance use (alcohol, tobacco, e-cigarette, marijuana, and other illegal drug use) is a growing public health concern in Latin America. In Central America,…

Date: 2025-09-17

HOXB7 drives bladder cancer progression via H-Ras/ERK signaling: a potential therapeutic target and prognostic biomarker

Abstract: Bladder cancer (BC) is a common malignancy characterized by high recurrence and poor prognosis. HOXB7, a member of the HOX gene family, is aberrantly expressed in…

Date: 2025-09-17

The clinical features and initial pharmacotherapeutic options of children with Tic disorders

Abstract: Tic disorders (TD) are common childhood neurodevelopmental conditions, characterized by diverse manifestations, leading to misdiagnosis and delayed therapy. Timely…

Date: 2025-09-17

Intestinal SURF4 in dyslipidaemia and female-specific metabolic disorders: insights from rats with polycystic ovary syndrome

Abstract: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and metabolic disturbances, including…

Date: 2025-09-17

Immunological reference intervals in pregnancy: longitudinal analysis of adaptive lymphocyte subsets

Abstract: Pregnancy induces profound immunological adaptations necessary to support fetal development while preserving maternal health. However, the systemic dynamics of…

Date: 2025-09-17

Tau protein mediates the association between frailty and postoperative delirium: a machine learning model incorporating cerebrospinal fluid biomarkers

Abstract: Postoperative delirium (POD) is a prevalent neurological complication linked to adverse clinical outcomes. The underlying mechanisms of POD remain unclear. This study…

Date: 2025-09-17

Association between vitamin D deficiency and risk of venous thromboembolism: a matched cohort study of 139,690 patients

Abstract: Vitamin D deficiency (VDD) may contribute to venous thromboembolism (VTE) through effects on coagulation and endothelial function, but existing studies show inconsistent…

Date: 2025-09-17

Establishment of local norms and standardization of the MATRICS consensus cognitive battery in Chinese adolescents

Abstract: The MATRICS Consensus Cognitive Battery (MCCB) is a widely used, standardized tool for assessing cognitive impairments in schizophrenia clinical trials. However,…

Date: 2025-09-17

Differences in the amplitude of dynamic low-frequency fluctuations in primary angle-closure glaucoma are associated with gene-molecular multi-omics

Abstract: Primary angle-closure glaucoma (PACG), an incurable ophthalmic disease, is a serious risk to human visual health. Previous studies have demonstrated a strong link…

Date: 2025-09-17

TFF2, a novel serum diagnostic biomarker for early pancreatic cancer

Abstract: Early detection and intervention are critical for improving the prognosis of pancreatic cancer (PC), but effective screening tests remain unavailable. A retrospective…

Date: 2025-09-17