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Comparative efficacy and safety of dexmedetomidine and midazolam for conscious sedation in blind nasotracheal intubation: a randomized controlled trial

Abstract: To evaluate the safety and efficacy of dexmedetomidine amnestic analgesia slow induction for blind nasotracheal intubation (BNTI) in oral and maxillofacial surgery.…

Date: 2025-11-27

Global and regional burdens of opioid use disorder from 1990 to 2021, with future forecasts to 2050: a systematic analysis for the global burden of disease study 2021

Abstract: This study comprehensively investigated the magnitude and temporal trends of the global burden of opioid use disorder (OUD) from 1990 to 2021 and predicted the disease…

Date: 2025-11-27

Development of a risk prediction model for acute kidney injury in liver transplant recipients

Abstract: To develop and internally validate a nomogram for early postoperative prediction of acute kidney injury (AKI) within 7 days after orthotopic liver transplantation (LT).…

Date: 2025-11-27

Nutritional and inflammatory markers for predicting delirium after radical hysterectomy for cervical cancer: development of a nomogram

Abstract: This investigation aimed to establish pivotal determinants of postoperative delirium (POD) following radical hysterectomy for cervical carcinoma (CC) and formulate an…

Date: 2025-11-27

Biological sex as a variable in immunity does not affect parabolic flight-induced alterations in immune responses

Abstract: The present era of spaceflight is accompanied by two meaningful breakthroughs. The access to in-orbit missions for civilians and the increasing enrolment of female…

Date: 2025-11-27

Effects of concentrated urine on complications and plasma creatinine: a prospective study in elective non-cardiac surgery patients

Abstract: The urine concentration of metabolic end products increases in response to low habitual water intake or acute dehydration. We examined the impact of concentrated urine…

Date: 2025-11-27

Lactate and lactylation in sepsis-associated acute kidney injury: clinical evidence from the MIMIC-IV database and mechanistic insights

Abstract: Sepsis-associated acute kidney injury (SA-AKI) is a common and severe complication of sepsis, yet early predictors remain limited. Lactate, beyond being a marker of…

Date: 2025-11-27

Longitudinal and cross-sectional predictors of sleep disturbance in a treatment follow-up sample with Tourette’s disorder

Abstract: Sleep disturbance is common in individuals with Tourette’s disorder (TD). Tic symptoms, medication, functional impairment, and psychiatric comorbidity frequently…

Date: 2025-11-27

Dynamic functional connectivity of the amygdala-hippocampal complex is associated with cognitive impairment in adolescents with Internet gaming disorder

Abstract: The amygdala-hippocampal complex (AHC) plays a central role in the neural mechanisms underlying Internet Gaming Disorder (IGD), particularly in emotional regulation,…

Date: 2025-11-27

EEG microstate analysis between patients with major depressive disorder, subclinical depression, and healthy controls

Abstract: Electroencephalography (EEG) microstates have emerged as potential biomarkers of large-scale brain network dynamics. However, their role in depression remains unclear…

Date: 2025-11-27