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A long-term retrospective analysis of oncologic and fertility outcomes in cervical cancer patients undergoing radical trachelectomy

Abstract: Given the excellent prognosis of early-stage cervical cancer, fertility-sparing surgery has grown as a priority, significant alternative for radical hysterectomy in…

Date: 2025-09-11

Global burden of disease among adolescents and young adults with drug use disorders, 1990–2021: based on GBD 2021

Abstract: The objective of this study was to assess the distribution and trends in the prevalence of drug use disorders (DUDs) among adolescents and young adults (aged 15 to 39…

Date: 2025-09-11

Virtual reality delivered exposure for fear of needles: a small-scale pilot

Abstract: Fear of needles significantly impacts individual and public health by leading many adults to avoid necessary medical procedures, including vaccinations and blood tests.…

Date: 2025-09-11

Latent profiles and associated factors of workplace violence among nurses in tertiary hospitals: a cross-sectional study

Abstract: Workplace violence (WPV) is a significant occupational hazard that threatens nurses’ psychological well-being and professional stability. Although prior studies have…

Date: 2025-09-11

The IBD-disk accurately assesses disability and psychological burden at IBD diagnosis and predicts adverse outcomes in both UC and Crohn’s disease during the first year of treatment: a prospective observational cohort study

Abstract: Inflammatory bowel disease (IBD) is linked with increased prevalence of mental health disorders (MHD), particularly anxiety and depression. How this influences treatment…

Date: 2025-09-11

Gain-of-function mutations in KATP channel subunits compromise colonic tight junction integrity and epithelial homeostasis in murine models of Cantú syndrome

Abstract: Cantú syndrome (CS) is a rare genetic disorder caused by gain-of-function (GOF) mutations in the KCNJ8 (Kir6.1) or ABCC9 (SUR2) subunits of ATP-sensitive potassium…

Date: 2025-09-11

Transcriptome-based immune subtypes reveal the heterogeneity of tumor microenvironment in pediatric B-cell acute lymphocytic leukemia

Abstract: Increasing evidence highlights the important role of the tumor microenvironment (TME) in B-cell acute lymphocytic leukemia (B-ALL). Our study aimed to stratify B-ALL…

Date: 2025-09-10

A retrospective analysis of inotuzumab ozogamicin usage in adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia

Abstract: The treatment of B-cell acute lymphoblastic leukemia (ALL) in India involves multi-agent chemotherapy and central nervous system (CNS) prophylaxis, but…

Date: 2025-09-10

Retrospective analysis of the efficacy and safety of anlotinib plus sintilimab (anti-PD-1) as maintenance therapy in advanced pediatric solid tumors

Abstract: Advanced solid tumors in children have limited maintenance treatment options. This study assessed the effectiveness and safety of anlotinib in conjunction with…

Date: 2025-09-10

Genetic and phenotypic heterogeneity of type 2 diabetes across Russian ancestry groups

Abstract: Type 2 diabetes mellitus (T2D) is a highly polygenic disease involving multiple biological pathways. Genetic ancestry may influence the predominant mechanisms driving…

Date: 2025-09-10