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The mutational landscape and actionable targets of gallbladder cancer: an ancestry-informed and comparative analysis of a Chilean population

Abstract: Gallbladder cancer (GBC) is a highly aggressive malignancy with one of the highest incidence rates reported in Chile. Despite its clinical impact, molecular…

Date: 2025-10-03

Development, feasibility and usability of an app for the correct nutrition of children and adolescents with acute lymphoblastic leukemia

Abstract: Proper nutrition during cancer treatment is crucial for children and adolescents with acute lymphoblastic leukemia (ALL), as malnutrition can impact treatment tolerance,…

Date: 2025-10-02

Ibrutinib combined with rituximab and high-dose methotrexate in newly diagnosed primary CNS diffuse large B-cell lymphoma: a pilot study with long-term follow-up

Abstract: IRM appears promising and well tolerated as first-line therapy for newly diagnosed PCNS DLBCL in a small pilot cohort; these hypothesis-generating results require…

Date: 2025-10-02

Noninvasive estimation of oxygenation index in pediatric critical care: an independent retrospective observational validation

Abstract: To independently validate an empirically optimized algorithm for calculating estimated Oxygenation Index (eOI) using noninvasive parameters from pediatric intensive care…

Date: 2025-10-02

Knowledge, attitudes, and practices toward assisted reproductive technology and painless egg retrieval among infertile women in the northwest region of China

Abstract: With the increasing use of assisted reproductive technology (ART) as a solution for infertility, understanding patient knowledge, attitudes, and practices (KAP) is…

Date: 2025-10-02

CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint

Abstract: Charged Multivesicular Body Protein 4A (CHMP4A), a member of the ESCRT-III family, plays a pivotal role in membrane remodeling and fission, with emerging evidence…

Date: 2025-10-02

Predictive modeling of acute radiation-induced dermatitis in nasopharyngeal carcinoma patients undergoing tomotherapy using machine learning with multimodal data integration

Abstract: Radiation dermatitis (RD) is a common and debilitating side effect of radiotherapy in nasopharyngeal carcinoma (NPC) patients. Traditional predictive models lack…

Date: 2025-10-02

Glycolysis-related radiosensitivity signature for predicting radiotherapy response in breast cancer

Abstract: This study investigates the influence of glycolytic activity on the efficacy of radiotherapy in breast cancer (BRCA) patients, aiming to develop a glycolysis-related…

Date: 2025-10-02

Multi-omics analyses inform mechanisms of immunotherapy response in pancreatic cancer

Abstract: Pancreatic ductal adenocarcinoma (PDAC) continues to exhibit resistance to immunotherapy. In this study, we evaluated the efficacy of combining immunotherapy with…

Date: 2025-10-02