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Reversed sex disparities in heart failure mortality in Spain, 2000–2023: a population-based analysis of older adults

Abstract: Heart failure (HF) is a growing public health concern in Spain, ranking as the third leading cause of cardiovascular mortality and contributing substantially to…

Date: 2025-09-01

Whole mitochondrial genome sequencing in individuals with Leber hereditary optic neuropathy negative for the common pathogenic mitochondrial DNA variants

Abstract: This study aimed to explore the role of additional mitochondrial DNA (mtDNA) variants in the development of Leber hereditary optic neuropathy (LHON) by screening the…

Date: 2025-09-01

Transformation of the private healthcare sector in the Republic of Kazakhstan following healthcare reforms

Abstract: In Kazakhstan, transformation of the private healthcare sector as the country transitioned from lower-middle-income to upper-middle-income status has rarely been a…

Date: 2025-09-01

Single-cell RNA-seq reveals a repair pattern in cystic lesions in steroid induced osteonecrosis of the femoral head

Abstract: Studies have indicated that cystic lesions play a crucial role in the repair processes of steroid-induced osteonecrosis of the femoral head and its subsequent collapse.…

Date: 2025-09-01

Comparative clinical outcomes of dual cannulated screw-cable system vs. Kirschner wire-cable fixation in type C patellar fractures

Abstract: To compare the clinical efficacy and safety of the dual cannulated screw-cable (DCSC) system with those of conventional Kirschner wire-cable (KWC) fixation in the…

Date: 2025-09-01

Bioinformatics-based analysis and experimental validation of PANoptosis-related biomarkers and immune infiltration in diabetic nephropathy

Abstract: Diabetic nephropathy (DN) is a frequent and serious microvascular complication of diabetes. PANoptosis is a novel mode of cell death that encompasses apoptosis, necrosis…

Date: 2025-09-01

Management of type I gastric-neuroendocrine tumors: the less the better?

Abstract: Type I gastric neuroendocrine tumors (gNETs) are known for their favorable prognosis. We aimed to present a real-life experience at a tertiary referral center.…

Date: 2025-09-01

Unanticipated discovery: basal metabolic rate as an independent risk factor for metabolic dysfunction-associated steatotic liver disease in a 5-year longitudinal cohort study of non-obese individuals in China

Abstract: The role of basal metabolic rate (BMR) in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) remains controversial, with previous studies yielding…

Date: 2025-09-01

Application of machine learning for prognostic modeling in unresectable pancreatic cancer treated with chemoradiotherapy

Abstract: Patients with unresectable pancreatic cancer have poor outcomes despite chemoradiotherapy (CRT). Traditional prognostic tools lack accuracy in predicting survival. This…

Date: 2025-09-01

Association of low serum 25-hydroxyvitamin D levels with hearing loss severity in Meniere disease: a cross-sectional study

Abstract: Growing evidence implicates vitamin D in inner ear homeostasis, though its association with Ménière’s disease (MD) remains incompletely characterized. This study aimed…

Date: 2025-09-01