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Idiopathic inflammatory myopathy associated with Sjögren’s disease: features of a distinct clinical entity

Abstract: Idiopathic inflammatory myopathies (IIM) and Sjögren’s disease (SjD) may coexist, but data on their combined presentation and treatment response remain limited. We…

Date: 2025-09-09

Artemisinin derivatives modulate KEAP1-NRF2-xCT pathway to alleviate Sjögren’s disease: insights from scRNA-seq and systems biology

Abstract: Sjögren’s Disease (SJD) is characterized by salivary gland dysfunction, and ferroptosis in salivary gland epithelial cells (SGECs) contributes to glandular damage.…

Date: 2025-09-09

Differential regulation of Treg stability in human naïve and effector Treg subsets by TGF?-signaling via ARKADIA-SKI axis

Abstract: The human FOXP3 + regulatory T (Treg) cells, a subset of CD4 + T cells with immunosuppressive function, are essential for the maintenance of immune homeostasis and…

Date: 2025-09-09

Increased risk of antiphospholipid syndrome in patients with psoriasis: a retrospective cohort study

Abstract: Psoriasis is associated with systemic inflammation and immune dysregulation, raising concerns about its potential link to antiphospholipid syndrome (APS). However,…

Date: 2025-09-09

Outstanding treatment success of pembrolizumab and bevacizumab combination therapy in first-line treatment of cervical sarcomatoid carcinoma: a rare case report

Abstract: Cervical lesions of sarcomatoid carcinoma are very rare, and there are still no reports of any targeted drugs applied in this rare tumor. In this report, we document a…

Date: 2025-09-08

Multi-omics reveals immune features in immune and non-immune cells, an IFN-?/IFN-?-B2M positive feedback loop, and targeted metabolic therapy in multiple myeloma

Abstract: Multiple myeloma (MM) is highly heterogeneous, with relapse occurring in the majority of cases, and recent advancements in single-cell RNA sequencing (scRNA-seq),…

Date: 2025-09-08

Urinary iodine concentration and thyroid function in pregnant women with hypertensive disorders

Abstract: Pregnant women are considered a risk group for iodine deficiency, and this condition may be associated with changes in thyroid hormone levels and an increased risk of…

Date: 2025-09-08

Age trend and risk factors of height loss in Chinese over 40 years old

Abstract: To evaluate age-related height loss trend in men and women in China, and analyze associated risk factors, we conducted a cross-sectional study among 1286 participants…

Date: 2025-09-08

Novel AVPR2 mutations in congenital nephrogenic diabetes insipidus: clinical characteristics and genetic analysis

Abstract: Congenital nephrogenic diabetes insipidus (NDI) is a rare hereditary disorder caused by mutations in two critical genes: arginine vasopressin receptor 2 (AVPR2) and…

Date: 2025-09-08

The 6-min walk test in transthyretin cardiac amyloidosis: prognostic utility put to the real-world test

Abstract: The 6-min walk test distance (6MWD) was identified as a predictor of mortality in transthyretin amyloid cardiomyopathy (ATTR-CM). However, its real-world applicability…

Date: 2025-09-08