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Explainable machine learning model to predict refeeding syndrome in patients with severe acute pancreatitis

Abstract: To construct and validate a risk prediction model for refeeding syndrome (RFS) in patients with severe acute pancreatitis (SAP), identify high-risk individuals before…

Date: 2026-01-23

Exosome-mediated bidirectional immune dysregulation in tuberculosis: proteomic profiling reveals strain-specific strategies of virulent H37Rv and attenuated H37Ra

Abstract: Tuberculosis (TB), caused by Mycobacterium tuberculosis ( Mtb ), remains a global health crisis, with drug resistance and immune evasion complicating control efforts.…

Date: 2026-01-23

Dynamic shifts in pathogen ecology of catheter-related bloodstream infections: temporal trends and ward-specific risk landscapes

Abstract: Catheter-related bloodstream infections (CRBSIs) represent a severe clinical complication with high mortality and pose a significant public health challenge due to…

Date: 2026-01-23

Influencing factors of initiation and maintenance of multidomain interventions in patients with mild cognitive impairment: a qualitative study

Abstract: Mild cognitive impairment (MCI) is a critical period for the prevention of dementia, and multidomain interventions can effectively delay and improve patients’ cognitive…

Date: 2026-01-23

Relationship between estimating glomerular filtration rate and cerebral large artery stenosis: a secondary analysis of a cross-sectional study

Abstract: Large cerebral artery stenosis (LCAS) is a risk factor for ischemic stroke; however, its relationship with kidney function remains unclear. This study aims to explore…

Date: 2026-01-23

Correlation of systemic immune inflammation index and systemic inflammatory response index with the severity of Parkinson’s disease

Abstract: While the significance of inflammation in Parkinson’s disease (PD) pathogenesis has been established, the relevance of emerging hematological markers such as the…

Date: 2026-01-23

Intracranial and extracranial artery stenosis and clinical outcome of acute ischemic stroke patients receiving intravenous thrombolysis

Abstract: Intracranial and/or extracranial atherosclerotic stenosis is a common etiology of acute ischemic stroke (AIS). This study aimed to evaluate the impact of intracranial or…

Date: 2026-01-23

Development of a prediction model for poor outcomes after thrombolysis in mild non-disabling ischemic stroke

Abstract: Mild non-disabling ischemic stroke (MNDIS) is increasingly treated with intravenous thrombolysis, yet a substantial proportion of patients still experience poor…

Date: 2026-01-23

Integration of single-cell sequencing, transcriptome sequencing, and machine learning for constructing and validating histone acetylation-related prognostic risk models in hepatocellular carcinoma

Abstract: Liver hepatocellular carcinoma (LIHC), a prevalent gastrointestinal malignancy, continues to demonstrate poor prognosis despite therapeutic advances improving clinical…

Date: 2026-01-23

Dinutuximab beta versus historical controls in the treatment of relapsed neuroblastoma: unadjusted and adjusted indirect comparisons

Abstract: Dinutuximab beta (dB) immunotherapy is used as maintenance treatment for relapsed/refractory neuroblastoma (NBL); however, comparative studies directly comparing dB with…

Date: 2026-01-22