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Research paper efficacy and safety of telitacicept combined with standard therapy for lupus nephritis: a single-center real-world study

Abstract: Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus with suboptimal response to standard therapy. This study evaluated the efficacy and safety…

Date: 2025-09-02

Safety and clinical outcomes of orelabrutinib, lenalidomide plus sintilimab for relapsed/refractory diffuse large B-cell lymphoma

Abstract: This study evaluated the safety and clinical outcomes of orelabrutinib, lenalidomide plus sintilimab in relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL).…

Date: 2025-09-01

The relationship between early adulthood obesity and sarcopenic obesity among middle-aged and older adults in the United States

Abstract: This study aimed to explore the relationship between early adulthood obesity and sarcopenic obesity (SO) among middle-aged and older adults in the United States. This…

Date: 2025-09-01

Impact of a high dietary fiber cereal meal intervention on the progression of liver fibrosis in T2DM with MASLD

Abstract: This study aimed to investigate the ameliorative effect of dietary fiber on hepatic fibrosis in T2DM combined with MASLD and to seek the appropriate dose of DF for this…

Date: 2025-09-01

Identifying aging-related biomarkers in adipose tissue using integrative bioinformatics and machine-learning approaches: discovery of ELN, MXD1, and FGF21 as key genes

Abstract: Adipose tissue plays a critical role in aging and age-related diseases. However, the specific molecular and cellular alterations associated with aging in adipose tissue…

Date: 2025-09-01

Assessing the association between the non-HDL to HDL cholesterol ratio and NAFLD in Chinese adults: concentrate on gout populations

Abstract: The coexistence and synergistic relationship between Nonalcoholic fatty liver disease (NAFLD) and gout necessitate an investigation into the risk factors for NAFLD among…

Date: 2025-09-01

Depression-associated reductions in putaminal volume are accompanied by a shift from matrix-like to striosome-like structural connectivity

Abstract: The striatum is among the most studied brain regions in Major Depressive Disorder (MDD) due to its involvement in reward, motivation, and executive functions. The…

Date: 2025-09-01

Development and validation of a nomogram for predicting early-onset severe intraventricular hemorrhage in extremely preterm infants

Abstract: Severe intraventricular hemorrhage (IVH) remains a major complication in extremely preterm infants, with significant clinical implications. We aimed to develop and…

Date: 2025-09-01

Health system resilience and pandemic response: a comparative analysis of China, Singapore, the U.S., and the U.K.

Abstract: Infectious disease outbreaks have imprinted unprecedentedly on global economies, societies, politics, and healthcare systems. The COVID-19 pandemic underscored critical…

Date: 2025-09-01

Pembrolizumab in the treatment of non-small cell lung cancer—experiences from clinical practice

Abstract: Immune checkpoint inhibitors (ICIs) have become the standard first-line treatment for patients with advanced or metastatic non-small cell lung cancer (NSCLC) without…

Date: 2025-09-01