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Global, regional, and national burden of Pediatric and adolescent thyroid cancer from 1990 to 2021: a statistical analysis of prevalence, incidence, and DALYs

Abstract: Thyroid cancer is the most common malignant tumor of the endocrine system. Among children and adolescents, cancer ranks as the fourth leading cause of cancer-related…

Date: 2025-07-29

Serum levels of interleukin-17, -18, -22, and -25 in patients with bullous pemphigoid before and after treatment

Abstract: This study aimed to explore the relationship between serum levels of interleukin-17 (IL-17), interleukin-18 (IL-18), interleukin-22 (IL-22), interleukin-25 (IL-25),…

Date: 2025-07-29

Burden of ageing spectrum of diseases in China, 1990–2021: a systematic analysis of global burden of disease study 2021

Abstract: Population aging represents a pressing challenge for China, given its vast population and the growing proportion of adults aged 65?years and older. The study aimed to…

Date: 2025-07-29

ROR?-activated mitophagy attenuating hypoxic-ischemic encephalopathy via suppression of microglial cGAS-STING axis

Abstract: Hypoxic-ischemic encephalopathy (HIE) involves neuroinflammation driven by microglial activation, yet regulatory mechanisms remain poorly defined. This study…

Date: 2025-07-29

Development and validation of a CD4+/CD8+ ratio-based nomogram to predict plastic bronchitis in pediatric Mycoplasma pneumoniae pneumonia

Abstract: Plastic bronchitis (PB) is a rare but severe complication of Mycoplasma pneumoniae pneumonia (MPP) in children. Early identification of PB is critical for timely…

Date: 2025-07-29

Risk factors associated with renal injury in patients initially diagnosed with IgA vasculitis

Abstract: To explore the risk factors associated with renal injury in patients diagnosed with IgA vasculitis at initial presentation. A retrospective analysis was conducted on the…

Date: 2025-07-29

Nutritional and immune-inflammatory scoring system for predicting outcomes in newly diagnosed diffuse large B-cell lymphoma patients

Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma and often carries a poor prognosis. Current prognostic systems such as the…

Date: 2025-07-28

Global, regional, and national anemia burden among women of reproductive age (15–49 years) from 1990 to 2021: an analysis of the Global Burden of Disease Study 2021

Abstract: Anemia remains a significant global health challenge, disproportionately affecting women of reproductive age (WRA, 15 to 49 years) due to physiological and socioeconomic…

Date: 2025-07-28

Downregulated PTEN and aberrant JAK–STAT signal pathway in essential thrombocythemia patients

Abstract: Background: Essential thrombocythemia (ET) is one of the Philadelphia-negative (Ph?) classical myeloproliferative neoplasms (MPNs), characterized by increased…

Date: 2025-05-23